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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Separation of caveolae from associated microdomains of GPI-anchored proteins.

In situ coating of the surface of endothelial cells in rat lung with cationic colloidal silica particles was used to separate caveolae from detergent-insoluble membranes rich in glycosyl phosphatidylinositol (GPI)-anchored proteins but devoid of caveolin. Immunogold electron microscopy showed that ganglioside GM1-enriched caveolae associated with an annular plasmalemmal domain enriched in GPI-anchored proteins. The purified caveolae contained molecular components required for regulated transport, including various lipid-anchored signaling molecules. Such specialized distinct microdomains may exist separately or together in the plasma membrane to organize signaling molecules and to process surface-bound ligands differentially.[1]


  1. Separation of caveolae from associated microdomains of GPI-anchored proteins. Schnitzer, J.E., McIntosh, D.P., Dvorak, A.M., Liu, J., Oh, P. Science (1995) [Pubmed]
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