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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Electroconvulsive shock alters GABAA receptor subunit mRNAs: use of quantitative PCR methodology.

Electroconvulsive shock (ECS) may affect several neurotransmitter systems in brain, including the GABAergic inhibitory system. We used a quantitative PCR-based assay to evaluate mRNAs for five GABAa receptor subunits at 2 to 24 h after ECS. mRNAs for the alpha 1 and beta 2 subunits were significantly increased in cerebellum at 4 and 8 h after ECS, and returned to control levels at 24 h. No changes were observed in alpha 2, beta 3, gamma 1, or gamma 2 subunits, and no changes in any subunit evaluated were observed in cortex or hippocampus. These data corroborate prior results obtained for the alpha 1 subunit using Northern hybridization, and illustrate the utility of the PCR assay in quantitating low-abundance mRNAs.[1]

References

  1. Electroconvulsive shock alters GABAA receptor subunit mRNAs: use of quantitative PCR methodology. Pratt, J.S., Kang, I., Bazan, N.G., Miller, L.G. Brain Res. Bull. (1993) [Pubmed]
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