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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.

Activation of the receptor tyrosine kinase ( RTK) torso defines the spatial domains of expression of the transcription factors tailless and huckebein. Previous analyses have demonstrated that Ras1 (p21ras) operates upstream of the D-Raf (Raf1) serine/threonine kinase in this signaling pathway. By using a recently developed technique of germline mosaics, we find that D-Raf can be activated by torso in the complete absence of Ras1. This result is supported by analysis of D-Raf activation in the absence of either the exchange factor Son of sevenless (Sos) or the adaptor protein drk (Grb2), as well as by the phenotype of a D-Raf mutation that abolishes binding of Ras1 to D-Raf. Our study provides in vivo evidence that Raf can be activated by an RTK in a Ras-independent pathway.[1]

References

  1. The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. Hou, X.S., Chou, T.B., Melnick, M.B., Perrimon, N. Cell (1995) [Pubmed]
 
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