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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Beneficial effect of an ACTH4-9 analogue on experimentally induced diabetic autonomic neuropathy in the eye of the rat under general anaesthesia.

While peripheral polyneuropathy is a well-known complication in diabetes mellitus, and the subject of a great deal of study, the clinical importance of autonomic diabetic neuropathy is increasingly recognised. Using an animal model, where the pupil diameter of the eye serves as a parameter of autonomic function, we produced an age and weight curve of pupil diameter and studied the development of autonomic neuropathy in rats with streptozotocin-induced diabetes. We show that diabetic rats develop significantly (P < 0.009) smaller pupils compared with controls, most probably due to a defective sympathetic input, caused by sympathetic neuropathy. Treatment with the neurotrophic peptide Org 2766, a synthetic ACTH4-9 analogue, prevents the occurrence of this sympathetic neuropathy, as the pupil diameters in the ACTH4-9 analogue-treated group are significantly (P < 0.05) larger than the pupils of placebo-treated rats, and are comparable to the pupil diameters of the rats in the control group.[1]

References

  1. Beneficial effect of an ACTH4-9 analogue on experimentally induced diabetic autonomic neuropathy in the eye of the rat under general anaesthesia. Vandertop, W.P., de Vries, W.B., Notermans, N.C., Tulleken, C.A., Gispen, W.H. J. Auton. Nerv. Syst. (1995) [Pubmed]
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