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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A study of gender, strain and age differences in mouse liver glutathione-S-transferase.

The hepatic cytosolic glutathione S-transferase ( GST) activity in four strains of the mouse and one strain of the rat was studied with the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), ethachrynic acid (ETHA), cumene hydroperoxide (CU) and atrazine as the in vitro substrates. In the mouse, significant gender, strain and age-related differences in the GST activity towards CDNB and atrazine were found between adolescent and sexually mature males and females of the CD-1, C57BL/6, DBA/2 and Swiss-Webster strains, and the differences were larger with atrazine as the substrate. With DCNB and CU a similar tendency was observed, however not significant for all strains. The GST activity towards ETHA was also gender and strain specific, but revealed no age-related differences. The herbicide atrazine seems to be a useful substrate in the study of strain and age-related differences in the mouse GST class Pi.[1]

References

  1. A study of gender, strain and age differences in mouse liver glutathione-S-transferase. Egaas, E., Falls, J.G., Dauterman, W.C. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1995) [Pubmed]
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