Disease relevance of Gstp1

• No change in the levels of expression of genes already known to be methylated in late-stage prostate cancer cells, such as glutathione S-transferase P1 and androgen receptor, was seen [1].
• Identification of glutathione S-transferase p-1 as the class pi form dominantly expressed in mouse hepatic adenomas [2].

High impact information on Gstp1

• To elucidate mechanisms underlying glutathione S-transferase p (GSTp)-mediated cellular protection against oxidative stress-induced cell death, the effect of GSTp on stress signaling pathways was investigated before and after H2O2 treatment [3].
• The sensitivity of cells to curcumin-induced apoptosis and the expression of GST P1 (but not heme oxygenase 1) are regulated by the epsilon isoform of protein kinase C (PKCepsilon) [4].
• Amongst class Pi transferase subunits, the constitutive hepatic level of mRNA for Gstp1 and Gstp2 was not substantially affected in the KO mice, but their induction by BHA was dependent on Nrf2; this was more obvious in female mutant mice than in male mice [5].
• Regulation of lipopolysaccharide-induced inflammatory response by glutathione S-transferase P1 in RAW264.7 cells [6].
• We previously reported the presence of a protein growth factor in rat adipose tissue which specifically permits the proliferation of 3T3-L1 and Ob1771 preadipocytes [Biochem. Biophys. Res. Commun. 1990;171:905-912, ref. 1] and which is hereinafter referred to as PAGF (preadipocyte growth factor) [7].

Biological context of Gstp1

• In addition to a TATA box and a sequence motif matching the phorbol-ester-responsive element, the promoters of Gst p-1 and Gst p-2 exhibit one and two G+C boxes (GGGCGG) respectively [8].
• Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases [3].
• Conversely, NLF become sensitive to curcumin-induced apoptosis and express lower levels of GST P1 when PKCepsilon expression or function is inhibited [4].
• Level of preadipocyte growth factor in rat adipose tissue which specifically permits the proliferation of preadipocytes is affected by restricted energy intake [7].
• Mouse lines lacking the P450s CYP1A1, CYP1A2, CYP1B1 and CYP2E1, microsomal epoxide hydrolase (mEH), NADPH:quinone oxidoreductase and the glutathione S-transferase P1 have no deleterious phenotypes, indicating that these enzymes are not required for mammalian development and physiological homeostasis [9].

Associations of Gstp1 with chemical compounds

• The herbicide atrazine seems to be a useful substrate in the study of strain and age-related differences in the mouse GST class Pi [10].

Other interactions of Gstp1

• Glutathione S-transferase-P1 and carbonic anhydrase III were significantly decreased in CFTR (-/-) mice with high SULT1E1 activity [11].

References