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Chemical Compound Review

DCNB     1,2-dichloro-4-nitro-benzene

Synonyms: PubChem2562, ARONIS24811, SureCN85918, CHEMBL167468, NSC-6295, ...
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Disease relevance of CCRIS 3097

  • The rabbit liver GST expressed in E. coli showed greater activity toward 1,2-dichloro-4-nitrobenzene than mu-class isozymes in rabbit hepatic tissue (T. Primiano and R.F. Novak (1993) Arch. Biochem. Biophys. 301, 404-410) [1].

Psychiatry related information on CCRIS 3097

  • We have reported the existence of low glutathione S-transferase (GST) dogs whose GST activity to 1,2-dichloro-4-nitrobenzene (DCNB) as a substrate (GST-D activity) is quite low, and have also reported significant individual differences in dog liver GST-D activity [2].

High impact information on CCRIS 3097


Biological context of CCRIS 3097


Anatomical context of CCRIS 3097


Associations of CCRIS 3097 with other chemical compounds


Gene context of CCRIS 3097


Analytical, diagnostic and therapeutic context of CCRIS 3097


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  2. Expression of the theta class GST isozyme, Yd(f)Yd (f), in low GST dogs. Watanabe, T., Ohashi, Y., Kosaka, T., Arakawa, S., Shibaya, Y., Yamoto, T., Manabe, S., Takasaki, W. Arch. Toxicol. (2006) [Pubmed]
  3. Expression of an enzymatically active Yb3 glutathione S-transferase in Escherichia coli and identification of its natural form in rat brain. Abramovitz, M., Ishigaki, S., Felix, A.M., Listowsky, I. J. Biol. Chem. (1988) [Pubmed]
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  7. Conjugation of model substrates or microsomally-activated aflatoxin B1 with reduced glutathione, catalysed by cytosolic glutathione-S-transferases in livers of rats, mice and guinea pigs. Neal, G.E., Nielsch, U., Judah, D.J., Hulbert, P.B. Biochem. Pharmacol. (1987) [Pubmed]
  8. Characterization of phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies using 1,2-dichloro-4-nitrobenzene. Fujimoto, K., Arakawa, S., Shibaya, Y., Miida, H., Ando, Y., Yasumo, H., Hara, A., Uchiyama, M., Iwabuchi, H., Takasaki, W., Manabe, S., Yamoto, T. Drug Metab. Dispos. (2006) [Pubmed]
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  10. Xenobiotic-metabolizing enzymes in the canine respiratory tract. Maier, K.L., Wippermann, U., Leuschel, L., Josten, M., Pflugmacher, S., Schröder, P., Sandermann, H., Takenaka, S., Ziesenis, A., Heyder, J. Inhalation toxicology. (1999) [Pubmed]
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  14. The effect of tridiphane (2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane) on hepatic epoxide-metabolizing enzymes: indications of peroxisome proliferation. Moody, D.E., Hammock, B.D. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  15. Activation of rat glutathione transferases in class mu by active oxygen species. Murata, T., Hatayama, I., Satoh, K., Tsuchida, S., Sato, K. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  16. Purification and characterization of glutathione-S-transferase from liver cytosol of phenobarbital-treated rabbits. Gawai, K.R., Pawar, S.S. Xenobiotica (1984) [Pubmed]
  17. Oxidative and conjugative metabolism of xenobiotics by livers of cattle, sheep, swine and rats. Smith, G.S., Watkins, J.B., Thompson, T.N., Rozman, K., Klaassen, C.D. J. Anim. Sci. (1984) [Pubmed]
  18. Induction of glutathione S-transferase P-form in primary cultured rat hepatocytes by epidermal growth factor and insulin. Hatayama, I., Yamada, Y., Tanaka, K., Ichihara, A., Sato, K. Jpn. J. Cancer Res. (1991) [Pubmed]
  19. Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro. Gyamfi, M.A., Ohtani, I.I., Shinno, E., Aniya, Y. Food Chem. Toxicol. (2004) [Pubmed]
  20. Induction of glutathione S-transferase isoenzymes in mouse liver by 5-(2-pyrazynl)-4-methyl-1,2-dithiole-3-thione (oltipraz). Nare, B., Smith, J.M., Prichard, R.K. Biochem. Pharmacol. (1992) [Pubmed]
  21. Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. II: Effects on conjugating enzymes. Leakey, J.A., Cunny, H.C., Bazare, J., Webb, P.J., Lipscomb, J.C., Slikker, W., Feuers, R.J., Duffy, P.H., Hart, R.W. Mech. Ageing Dev. (1989) [Pubmed]
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