The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

DCNB     1,2-dichloro-4-nitro-benzene

Synonyms: PubChem2562, ARONIS24811, SureCN85918, CHEMBL167468, NSC-6295, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of CCRIS 3097

  • The rabbit liver GST expressed in E. coli showed greater activity toward 1,2-dichloro-4-nitrobenzene than mu-class isozymes in rabbit hepatic tissue (T. Primiano and R.F. Novak (1993) Arch. Biochem. Biophys. 301, 404-410) [1].
 

Psychiatry related information on CCRIS 3097

  • We have reported the existence of low glutathione S-transferase (GST) dogs whose GST activity to 1,2-dichloro-4-nitrobenzene (DCNB) as a substrate (GST-D activity) is quite low, and have also reported significant individual differences in dog liver GST-D activity [2].
 

High impact information on CCRIS 3097

 

Biological context of CCRIS 3097

 

Anatomical context of CCRIS 3097

 

Associations of CCRIS 3097 with other chemical compounds

 

Gene context of CCRIS 3097

 

Analytical, diagnostic and therapeutic context of CCRIS 3097

References

  1. Cloning and expression of a cDNA for mu-class glutathione S-transferase from rabbit liver. Lee, S.H., Lee, S.H., Han, J.S., Kim, Y.S., Koh, J.K. Arch. Biochem. Biophys. (1995) [Pubmed]
  2. Expression of the theta class GST isozyme, Yd(f)Yd (f), in low GST dogs. Watanabe, T., Ohashi, Y., Kosaka, T., Arakawa, S., Shibaya, Y., Yamoto, T., Manabe, S., Takasaki, W. Arch. Toxicol. (2006) [Pubmed]
  3. Expression of an enzymatically active Yb3 glutathione S-transferase in Escherichia coli and identification of its natural form in rat brain. Abramovitz, M., Ishigaki, S., Felix, A.M., Listowsky, I. J. Biol. Chem. (1988) [Pubmed]
  4. Human variability in hepatic glutathione S-transferase-mediated conjugation of aflatoxin B1-epoxide and other substrates. Slone, D.H., Gallagher, E.P., Ramsdell, H.S., Rettie, A.E., Stapleton, P.L., Berlad, L.G., Eaton, D.L. Pharmacogenetics (1995) [Pubmed]
  5. Different drug metabolizing capacities in cultured periportal and pericentral hepatocytes. Gebhardt, R., Alber, J., Wegner, H., Mecke, D. Biochem. Pharmacol. (1994) [Pubmed]
  6. Conjugation reactions in hepatocytes isolated from streptozotocin-induced diabetic rats. Grant, M.H., Duthie, S.J. Biochem. Pharmacol. (1987) [Pubmed]
  7. Conjugation of model substrates or microsomally-activated aflatoxin B1 with reduced glutathione, catalysed by cytosolic glutathione-S-transferases in livers of rats, mice and guinea pigs. Neal, G.E., Nielsch, U., Judah, D.J., Hulbert, P.B. Biochem. Pharmacol. (1987) [Pubmed]
  8. Characterization of phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies using 1,2-dichloro-4-nitrobenzene. Fujimoto, K., Arakawa, S., Shibaya, Y., Miida, H., Ando, Y., Yasumo, H., Hara, A., Uchiyama, M., Iwabuchi, H., Takasaki, W., Manabe, S., Yamoto, T. Drug Metab. Dispos. (2006) [Pubmed]
  9. Effects of aging on hepatic and pulmonary glutathione S-transferase activities in male and female Fischer 344 rats. Spearman, M.E., Leibman, K.C. Biochem. Pharmacol. (1984) [Pubmed]
  10. Xenobiotic-metabolizing enzymes in the canine respiratory tract. Maier, K.L., Wippermann, U., Leuschel, L., Josten, M., Pflugmacher, S., Schröder, P., Sandermann, H., Takenaka, S., Ziesenis, A., Heyder, J. Inhalation toxicology. (1999) [Pubmed]
  11. Characterization of a novel microsomal glutathione S-transferase produced by Aspergillus ochraceus TS. Datta, J., Samanta, T.B. Mol. Cell. Biochem. (1992) [Pubmed]
  12. Human Mu-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue. Hussey, A.J., Hayes, J.D. Biochim. Biophys. Acta (1993) [Pubmed]
  13. Impairment of hepatic glutathione S-transferase activity as a cause of reduced biliary sulfobromophthalein excretion in clofibrate-treated rats. Foliot, A., Touchard, D., Celier, C. Biochem. Pharmacol. (1984) [Pubmed]
  14. The effect of tridiphane (2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane) on hepatic epoxide-metabolizing enzymes: indications of peroxisome proliferation. Moody, D.E., Hammock, B.D. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  15. Activation of rat glutathione transferases in class mu by active oxygen species. Murata, T., Hatayama, I., Satoh, K., Tsuchida, S., Sato, K. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  16. Purification and characterization of glutathione-S-transferase from liver cytosol of phenobarbital-treated rabbits. Gawai, K.R., Pawar, S.S. Xenobiotica (1984) [Pubmed]
  17. Oxidative and conjugative metabolism of xenobiotics by livers of cattle, sheep, swine and rats. Smith, G.S., Watkins, J.B., Thompson, T.N., Rozman, K., Klaassen, C.D. J. Anim. Sci. (1984) [Pubmed]
  18. Induction of glutathione S-transferase P-form in primary cultured rat hepatocytes by epidermal growth factor and insulin. Hatayama, I., Yamada, Y., Tanaka, K., Ichihara, A., Sato, K. Jpn. J. Cancer Res. (1991) [Pubmed]
  19. Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro. Gyamfi, M.A., Ohtani, I.I., Shinno, E., Aniya, Y. Food Chem. Toxicol. (2004) [Pubmed]
  20. Induction of glutathione S-transferase isoenzymes in mouse liver by 5-(2-pyrazynl)-4-methyl-1,2-dithiole-3-thione (oltipraz). Nare, B., Smith, J.M., Prichard, R.K. Biochem. Pharmacol. (1992) [Pubmed]
  21. Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. II: Effects on conjugating enzymes. Leakey, J.A., Cunny, H.C., Bazare, J., Webb, P.J., Lipscomb, J.C., Slikker, W., Feuers, R.J., Duffy, P.H., Hart, R.W. Mech. Ageing Dev. (1989) [Pubmed]
 
WikiGenes - Universities