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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Control of transcription by Krüppel through interactions with TFIIB and TFIIE beta.

The zinc-finger protein Krüppel ( Kr) is an integral part of the Drosophila segmentation gene cascade and is essential in organogenesis during later embryonic development. In tissue culture, Kr regulates transcription. Monomeric Kr can act as a transcriptional activator, whereas Kr dimers formed at high concentrations cause repression. Here we show that Kr-dependent control of transcription involves functional interactions with components of the basal RNA polymerase II transcription machinery, which includes the initiation factors TFIIA, B, E, F, H and I (refs 10, 11) as well as the TATA-binding protein (TBP) and TBP-associated factors (TAFs) contained in the multisubunit TFIID ( ref. 12). Our results indicate that when acting from a site close to a basal promoter, monomeric Kr interacts with TFIIB to activate transcription, whereas an interaction of the Kr dimer with TFIIE beta, a subunit of TFIIE, results in transcriptional repression.[1]


  1. Control of transcription by Krüppel through interactions with TFIIB and TFIIE beta. Sauer, F., Fondell, J.D., Ohkuma, Y., Roeder, R.G., Jäckle, H. Nature (1995) [Pubmed]
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