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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Khat chewing delays gastric emptying of a semi-solid meal.

BACKGROUND: The leaves of Khat are chewed for their central stimulant effect, but their use may cause anorexia and constipation. METHODS: Gastric emptying of a radio-labelled semi-solid meal was measured in 12 healthy volunteers on two occasions a week apart. Subjects chewed either Khat leaves (Catha edulis) or lettuce for 2 h before the study. RESULTS: Gastric emptying was significantly (P < 0.02) prolonged after chewing Khat compared with lettuce. CONCLUSION: The sympathomimetic action of cathinone in Khat may cause the observed delay in gastric emptying.[1]


  1. Khat chewing delays gastric emptying of a semi-solid meal. Heymann, T.D., Bhupulan, A., Zureikat, N.E., Bomanji, J., Drinkwater, C., Giles, P., Murray-Lyon, I.M. Aliment. Pharmacol. Ther. (1995) [Pubmed]
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