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MeSH Review

Catha

 
 
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High impact information on Catha

  • Studies of the regulation of ERK1/2-p42, 44 by Ucn-I were extended to cell lines that endogenously express CRFR1 (AtT-20 and CATHa cells) and CRFR2 (A7r5 and CATHa cells) [1].
  • The defined location of the GAL monomer in the complex with 35% of its surface covered by the CathA dimer may explain the stabilizing effect of CathA on GAL in lysosome [2].
  • Khat extract was shown to contain the major alkaloid compounds cathinone and cathine [3].
  • It was concluded that the two antibiotics, particularly ampicillin, should be taken 2 h after Khat chewing [4].
  • The study examined the effect of Khat chewing on ampicillin and amoxycillin bioavailability following the administration of a 500 mg single dose of each antibiotic at different times relative to Khat chewing [4].
 

Biological context of Catha

 

Anatomical context of Catha

  • Genotoxicity of the methanolic extract of khat (Catha edulis) has been evaluated on the male germ cells using the dominant lethal assay procedure in Swiss albino mice [7].
 

Associations of Catha with chemical compounds

  • Cathinone is an active ingredient in the leaves of the Khat shrub [8].
  • The potency of dl-cathinone (the active constituent of the Khat plant) was compared with that of d-amphetamine in the conditioned taste aversion (C.T.A.) procedure and in a test of drug-induced adipsia in rats [9].
  • We have compared the analgesic properties of khat (Catha edulis Forsk) extract, amphetamine and ibuprofen in mice [10].
  • Anorexigenic effects of two amines obtained from Catha edulis Forsk. (Khat) in rats [11].
  • Cathinone (Khat) and methcathinone (CAT) in urine specimens: a gas chromatographic-mass spectrometric detection procedure [12].
 

Gene context of Catha

  • The 32/20-kDa two-chain form of protective protein/cathepsin A (CathA) secreted by human platelets was thermostable in the aggregation supernatant at acidic pH, but was denatured at neutral pH [13].
  • The induction of dominant lethal mutations upon chronic administration of khat (Catha edulis) in albino mice [14].
  • Khat (Catha edulis) up-regulates testosterone and decreases prolactin and cortisol levels in the baboon [15].
  • These factors include chewing tobacco and snuff, areca nut in its various forms, Khat leaves, and the drinking of Mate [16].
 

Analytical, diagnostic and therapeutic context of Catha

  • The effects of repeated oral administration of the psychostimulant plant, Catha edulis and its active principle, cathinone on rats were studied using isolation induced aggression paradigm [17].

References

  1. Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides. Brar, B.K., Chen, A., Perrin, M.H., Vale, W. Endocrinology (2004) [Pubmed]
  2. Human lysosomal beta-galactosidase-cathepsin A complex: definition of the beta-galactosidase-binding interface on cathepsin A. Pshezhetsky, A.V., Elsliger, M.A., Vinogradova, M.V., Potier, M. Biochemistry (1995) [Pubmed]
  3. Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells. Dimba, E.A., Gjertsen, B.T., Bredholt, T., Fossan, K.O., Costea, D.E., Francis, G.W., Johannessen, A.C., Vintermyr, O.K. Br. J. Cancer (2004) [Pubmed]
  4. Effect of Khat chewing on the bioavailability of ampicillin and amoxycillin. Attef, O.A., Ali, A.A., Ali, H.M. J. Antimicrob. Chemother. (1997) [Pubmed]
  5. Khat chewing delays gastric emptying of a semi-solid meal. Heymann, T.D., Bhupulan, A., Zureikat, N.E., Bomanji, J., Drinkwater, C., Giles, P., Murray-Lyon, I.M. Aliment. Pharmacol. Ther. (1995) [Pubmed]
  6. Effect of Catha edulis (khat) chewing on plasma lipid peroxidation. Al-Zubairi, A., Al-Habori, M., Al-Geiry, A. Journal of ethnopharmacology. (2003) [Pubmed]
  7. Evaluation of genotoxic potential of khat (Catha edulis) in Swiss albino mice. Tariq, M., Al-Meshal, I.A., Parmar, N.S., Ageel, A.M., Qureshi, S. Mutagenesis (1986) [Pubmed]
  8. Cathinone affects dopamine and 5-hydroxytryptamine neurons in vivo as measured by changes in metabolites and synthesis in four forebrain regions in the rat. Nielsen, J.A. Neuropharmacology (1985) [Pubmed]
  9. The puzzle of drug-induced conditioned taste aversion: comparative studies with cathinone and amphetamine. Goudie, A.J., Newton, T. Psychopharmacology (Berl.) (1985) [Pubmed]
  10. Comparison of analgesic effects of khat (Catha edulis Forsk) extract, D-amphetamine and ibuprofen in mice. Connor, J., Makonnen, E., Rostom, A. J. Pharm. Pharmacol. (2000) [Pubmed]
  11. Anorexigenic effects of two amines obtained from Catha edulis Forsk. (Khat) in rats. Zelger, J.L., Carlini, E.A. Pharmacol. Biochem. Behav. (1980) [Pubmed]
  12. Cathinone (Khat) and methcathinone (CAT) in urine specimens: a gas chromatographic-mass spectrometric detection procedure. Paul, B.D., Cole, K.A. Journal of analytical toxicology. (2001) [Pubmed]
  13. Stabilizing effect of lysosomal beta-galactosidase on the catalytic activity of protective protein/cathepsin A secreted by human platelets. Itoh, K., Naganawa, Y., Kamei, S., Shimmoto, M., Sakuraba, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  14. The induction of dominant lethal mutations upon chronic administration of khat (Catha edulis) in albino mice. Tariq, M., Qureshi, S., Ageel, A.M., al-Meshal, I.A. Toxicol. Lett. (1990) [Pubmed]
  15. Khat (Catha edulis) up-regulates testosterone and decreases prolactin and cortisol levels in the baboon. Mwenda, J.M., Owuor, R.A., Kyama, C.M., Wango, E.O., M'Arimi, M., Langat, D.K. Journal of ethnopharmacology. (2006) [Pubmed]
  16. Habitual risk factors for head and neck cancer. Goldenberg, D., Lee, J., Koch, W.M., Kim, M.M., Trink, B., Sidransky, D., Moon, C.S. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2004) [Pubmed]
  17. Repeated Catha edulis oral administration enhances the baseline aggressive behavior in isolated rats. Banjaw, M.Y., Miczek, K., Schmidt, W.J. Journal of neural transmission (Vienna, Austria : 1996) (2006) [Pubmed]
 
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