High impact information on Catha

• Studies of the regulation of ERK1/2-p42, 44 by Ucn-I were extended to cell lines that endogenously express CRFR1 (AtT-20 and CATHa cells) and CRFR2 (A7r5 and CATHa cells) [1].
• The defined location of the GAL monomer in the complex with 35% of its surface covered by the CathA dimer may explain the stabilizing effect of CathA on GAL in lysosome [2].
• Khat extract was shown to contain the major alkaloid compounds cathinone and cathine [3].
• It was concluded that the two antibiotics, particularly ampicillin, should be taken 2 h after Khat chewing [4].
• The study examined the effect of Khat chewing on ampicillin and amoxycillin bioavailability following the administration of a 500 mg single dose of each antibiotic at different times relative to Khat chewing [4].

Biological context of Catha

• CONCLUSION: The sympathomimetic action of cathinone in Khat may cause the observed delay in gastric emptying [5].
• The effect of regular khat (Catha edulis) chewing and the combination of khat chewing and smoking on plasma lipid peroxidation as a biomarker of oxidative stress and free radical activity (measured as plasma malondialdehyde, MDA), as well as on the lipid profiles were investigated [6].

Anatomical context of Catha

• Genotoxicity of the methanolic extract of khat (Catha edulis) has been evaluated on the male germ cells using the dominant lethal assay procedure in Swiss albino mice [7].

Associations of Catha with chemical compounds

• Cathinone is an active ingredient in the leaves of the Khat shrub [8].
• The potency of dl-cathinone (the active constituent of the Khat plant) was compared with that of d-amphetamine in the conditioned taste aversion (C.T.A.) procedure and in a test of drug-induced adipsia in rats [9].
• We have compared the analgesic properties of khat (Catha edulis Forsk) extract, amphetamine and ibuprofen in mice [10].
• Anorexigenic effects of two amines obtained from Catha edulis Forsk. (Khat) in rats [11].
• Cathinone (Khat) and methcathinone (CAT) in urine specimens: a gas chromatographic-mass spectrometric detection procedure [12].

Gene context of Catha

• The 32/20-kDa two-chain form of protective protein/cathepsin A (CathA) secreted by human platelets was thermostable in the aggregation supernatant at acidic pH, but was denatured at neutral pH [13].
• The induction of dominant lethal mutations upon chronic administration of khat (Catha edulis) in albino mice [14].
• Khat (Catha edulis) up-regulates testosterone and decreases prolactin and cortisol levels in the baboon [15].
• These factors include chewing tobacco and snuff, areca nut in its various forms, Khat leaves, and the drinking of Mate [16].

Analytical, diagnostic and therapeutic context of Catha

• The effects of repeated oral administration of the psychostimulant plant, Catha edulis and its active principle, cathinone on rats were studied using isolation induced aggression paradigm [17].

References