Disease relevance of l-Cathinone

• These effects were closely similar to those observed after cathinone, 0.5 mg/kg body weight, although peak plasma concentrations of cathinone after khat were delayed [1].
• Since cocaine is linked to an increased incidence of myocardial infarction, these results may have implications in terms of cardiac morbidity of amphetamine derivatives and cathinone [2].
• An evaluation of the male reproductive toxicity of cathinone [3].
• This case showed that the consumption of bromazepam and alcohol altered the typical clinical symptoms of cathinone derivative intoxication, namely hypertension and convulsions [4].
• Re: cathinone: a new differential in the diagnosis of pregnancy induced hypertension [5].

Psychiatry related information on l-Cathinone

• The present study expanded upon this earlier work by examining the dose-response nature of cathinone-induced conditioned place preference, as well as testing its effect upon spontaneous locomotor activity [6].
• Role of instrumental learning in tolerance to cathinone hypophagia [7].
• However, the N-monomethyl derivative of cathinone (i.e., methcathinone), like cathinone, resulted in stimulus generalization [8].

High impact information on l-Cathinone

• Chiral resolution of a number of cationic drugs of forensic interest (amphetamine, methamphetamine, cathinone, methcathinone, cathine, cocaine, propoxyphene, and various alpha-hydroxyphenethylamines) is achieved via capillary electrophoresis (CE) with added cyclodextrins (CDs), including novel mixtures of neutral and anionic CDs [9].
• CONCLUSION: The sympathomimetic action of cathinone in Khat may cause the observed delay in gastric emptying [10].
• The effects of (-)cathinone, the primary psychoactive alkaloid of the Khat plant, were compared to those of (+)amphetamine in the anterior caudate-putamen and the nucleus accumbens [11].
• In the present study, the potency of (-)cathinone in inducing the release of radioactivity from 3H-dopamine prelabelled tissue of the rat caudate nucleus was compared to that of several structural analogs, i.e. to that of four other aminophenones [12].
• The two isomers of cathinone were found to be approximately equipotent in inducing release at peripheral noradrenergic nerve endings, but the (-)isomer was about three times more potent than the (+)isomer at dopamine terminals in the CNS [13].

Chemical compound and disease context of l-Cathinone

• Differential effects of nicotine but not cathinone on motor activity of P and NP rats [14].

Biological context of l-Cathinone

• Cathinone, the main active substance in fresh khat leaves, has sympathomimetic effects which increase heart rate and blood pressure [15].
• 2. Cathinone produced increases in blood pressure and in heart rate, and these changes were concomitant with the presence of cathinone in blood plasma [16].
• The observed biotransformation of cathinone to the less potent psychostimulant, d-norpseudoephedrine involves reduction of a ketone group to alcohol, a common metabolic pathway in humans [17].
• In rat left ventricular slices, potency (-log IC50) values at inhibiting uptake of [3H]noradrenaline were: cocaine 6.16+/-0.15, cathinone 6.03+/-0.16, MDMA 6.05+/-0.07, MDA 5.68+/-0.06 and MDEA 5.56+/-0.08 [18].
• Although this and previous studies have demonstrated that significant parallelisms exist between the structure-activity relationships of amphetamine analogs and cathinone analogs, we now report several unexpected qualitative and/or quantitative differences [19].

Anatomical context of l-Cathinone

• This was done by measuring the release of radioactivity in response to the cathinone isomers, from tissue slices taken from different areas of the nervous system of the rat and prelabelled with tritiated catecholamines ([3H]dopamine: nucleus accumbens and nucleus caudatus; [3H]noradrenaline: atrium and vas deferens) [13].
• Effect of cathinone on chick embryo heart [20].
• Conversely, exposure to either (S) or (R) isomers of cathinone resulted in stimulation of IL-2 production, B-lymphocyte proliferation, and CTL induction [21].
• This effect is believed to be caused by the sympathomimetic action of cathinone on the central nervous system [22].

Associations of l-Cathinone with other chemical compounds

• (1) Cathinone potentiated morphine analgesia and the whole effect was antagonized by naloxone whereas onto the cathinone potentiation was counteracted by phenoxybenzamine [23].
• A gas chromatographic-mass spectrometric procedure for detection of cathinone (Khat) and methcathinone (CAT) in urine was developed [24].
• A behavioral comparison of Nexus, cathinone, BDB, and MDA [25].
• This indicates that the coronary vasoconstriction by cathinone was not due to an action on alpha(1)-adrenoceptors either directly or indirectly through noradrenaline release [26].

Gene context of l-Cathinone

• Histopathological examination of testes revealed degeneration of interstitial tissue, cellular infiltration and atrophy of Sertoli and Leydig's cells in cathinone treated animals [3].
• The increase in plasma ACTH induced by the tail-flick test at 30 min and 24 h was significantly enhanced by cathinone, in a naloxone-reversible way [27].

Analytical, diagnostic and therapeutic context of l-Cathinone

• This effect is thought to be attributable to the phenylalkylamine cathinone, but no controlled clinical trials have been published [1].
• Involvement of monoaminergic and peptidergic components in cathinone-induced analgesia [23].
• The results of this experiment show that repeated oral administration of cathinone or C. edulis extract enhanced locomotor and exploratory activity and lead to a gradual deficit in prepulse inhibition [28].
• In infra-human species cathinone is an effective positive reinforcer (i.e., it maintains self-administration) [29].
• In order to determine the effects of this substance in humans, a single oral dose of cathinone or placebo was administered to six healthy male volunteers in a double-blind, random order crossover study [16].

References