The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

X region deletion mutants associated with surface antigen-positive hepatitis B virus infections.

BACKGROUND/AIMS: The finding of antibodies against the polymerase of hepatitis B virus in renal dialysis patients before the incubation phase of infection implies underlying virus replication. Hence, the aim of the study was to test for virus during infection. METHODS: Viremia was assayed in virus-infected and control patients using the polymerase chain reaction and Southern blotting. RESULTS: Six months before the appearance of surface antigen, most patients had detectable core region, but few patients were X region positive. Three months after surface antigen appeared, most carriers had detectable core and X products. Three years after surface antigen appeared, 5 of 8 carriers with persistent hepatitis B e antigen and 1 of 8 carriers with corresponding antibody had these products. Cloning and sequencing showed deletions within the X/precore region of viral DNA. CONCLUSIONS: Infection with X region mutants precedes that of wild-type virus, and they reappear after wild-type virus is eliminated in carriers.[1]


  1. X region deletion mutants associated with surface antigen-positive hepatitis B virus infections. Feitelson, M.A., Duan, L.X., Guo, J., Blumberg, B.S. Gastroenterology (1995) [Pubmed]
WikiGenes - Universities