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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Amantadine versus trihexyphenidyl in the treatment of neuroleptic-induced parkinsonism.

Amantadine is a putative dopaminergic compound known to be therapeutically effective in idiopathic and postencephalitic Parkinson's disease. In a double-blind placebo-controlled crossover study of 39 psychiatric inpatients, amantadine and trihexyphenidyl were equally effective in treating drug-induced parkinsonism, and amantadine produced fewer and less severe side effects. The authors suggest that amantadine is an effective alternative to atropine-like agents, with fewer implications for long-term risk of tardive dyskinesia.[1]

References

  1. Amantadine versus trihexyphenidyl in the treatment of neuroleptic-induced parkinsonism. Fann, W.E., Lake, C.R. The American journal of psychiatry. (1976) [Pubmed]
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