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Chemical Compound Review

ATROPINE     [(1R,5S)-8-methyl-8- azabicyclo[3.2.1]oct-3...

Synonyms: Atropair, Atropina, Atrosulf, Cytospaz, Anaspaz, ...
 
 
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Disease relevance of Atropinol

 

Psychiatry related information on Atropinol

 

High impact information on Atropinol

  • Thus, although its diagnostic sensitivity is low, pancreatic polypeptide appears to be a useful adjunctive marker of many pancreatic endocrine tumors, and the atropine suppression test can be used to distinguish normal from tumor-related secretion of the polypeptide [11].
  • In M. mulatta, atropine is ineffective; furthermore, myopia develops when lids are sutured after interruption of the optic pathways [12].
  • Local application of the GABA agonist muscimol prevents the appearance of seizures on subsequent microinjection of all convulsant agents examined, whereas local application of the muscarinic antagonist, atropine, only prevents seizures induced by carbachol [13].
  • Furthermore, atropine-resistant contractions of bladder smooth muscle are thought to be mediated by ATP, while in situ experiments in vesical parasympathetic ganglia have suggested that a purinergic modulatory mechanism may control urinary bladder function [14].
  • Vasoactive intestinal polypeptide and muscarinic receptors: supersensitivity induced by long-term atropine treatment [15].
 

Chemical compound and disease context of Atropinol

 

Biological context of Atropinol

 

Anatomical context of Atropinol

 

Associations of Atropinol with other chemical compounds

 

Gene context of Atropinol

  • Atropine or inhibitors of MAPK phosphorylation blocked these effects [35].
  • The cholinergic agonist pilocarpine and electrostimulation of the sciatic nerve both elicited a sweat response in adult DBH -/- mice that was indistinguishable from the response of controls, and the cholinergic antagonist atropine effectively blocked these responses [36].
  • The developmental increase in atrial CNTF receptor mRNA was enhanced by stimulating muscarinic receptors with carbachol in ovo and was inhibited by blocking muscarinic cholinergic receptors with atropine [37].
  • The receptor expressed in zinc-induced cells exhibits the high affinity binding for quinuclidinyl benzilate, atropine, and pirenzepine expected of the M1 muscarinic receptor [38].
  • Conversely, atropine pretreatment significantly (P less than 0.01) blocked the GH response to GHRH challenge, whereas yohimbine did not significantly affect it [39].
 

Analytical, diagnostic and therapeutic context of Atropinol

References

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  35. Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells. Cheng, K., Zimniak, P., Raufman, J.P. Cancer Res. (2003) [Pubmed]
  36. Norepinephrine facilitates the development of the murine sweat response but is not essential. Tafari, A.T., Thomas, S.A., Palmiter, R.D. J. Neurosci. (1997) [Pubmed]
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  39. Evidence that alpha 2-adrenergic pathways play a major role in growth hormone (GH) neuroregulation: alpha 2-adrenergic agonism counteracts the inhibitory effect of muscarinic cholinergic receptor blockade on the GH response to GH-releasing hormone, while alpha 2-adrenergic blockade diminishes the potentiating effect of increased cholinergic tone on such stimulation in normal men. Devesa, J., Diaz, M.J., Tresguerres, J.A., Arce, V., Lima, L. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
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