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Chemical Compound Review

ATROPINE     [(1R,5S)-8-methyl-8- azabicyclo[3.2.1]oct-3...

Synonyms: Atropair, Atropina, Atrosulf, Cytospaz, Anaspaz, ...
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Disease relevance of Atropinol


Psychiatry related information on Atropinol


High impact information on Atropinol

  • Thus, although its diagnostic sensitivity is low, pancreatic polypeptide appears to be a useful adjunctive marker of many pancreatic endocrine tumors, and the atropine suppression test can be used to distinguish normal from tumor-related secretion of the polypeptide [11].
  • In M. mulatta, atropine is ineffective; furthermore, myopia develops when lids are sutured after interruption of the optic pathways [12].
  • Local application of the GABA agonist muscimol prevents the appearance of seizures on subsequent microinjection of all convulsant agents examined, whereas local application of the muscarinic antagonist, atropine, only prevents seizures induced by carbachol [13].
  • Furthermore, atropine-resistant contractions of bladder smooth muscle are thought to be mediated by ATP, while in situ experiments in vesical parasympathetic ganglia have suggested that a purinergic modulatory mechanism may control urinary bladder function [14].
  • Vasoactive intestinal polypeptide and muscarinic receptors: supersensitivity induced by long-term atropine treatment [15].

Chemical compound and disease context of Atropinol


Biological context of Atropinol


Anatomical context of Atropinol


Associations of Atropinol with other chemical compounds


Gene context of Atropinol

  • Atropine or inhibitors of MAPK phosphorylation blocked these effects [35].
  • The cholinergic agonist pilocarpine and electrostimulation of the sciatic nerve both elicited a sweat response in adult DBH -/- mice that was indistinguishable from the response of controls, and the cholinergic antagonist atropine effectively blocked these responses [36].
  • The developmental increase in atrial CNTF receptor mRNA was enhanced by stimulating muscarinic receptors with carbachol in ovo and was inhibited by blocking muscarinic cholinergic receptors with atropine [37].
  • The receptor expressed in zinc-induced cells exhibits the high affinity binding for quinuclidinyl benzilate, atropine, and pirenzepine expected of the M1 muscarinic receptor [38].
  • Conversely, atropine pretreatment significantly (P less than 0.01) blocked the GH response to GHRH challenge, whereas yohimbine did not significantly affect it [39].

Analytical, diagnostic and therapeutic context of Atropinol


  1. Neostigmine for the treatment of acute colonic pseudo-obstruction. Ponec, R.J., Saunders, M.D., Kimmey, M.B. N. Engl. J. Med. (1999) [Pubmed]
  2. Long-term synaptic potentiation in the superior cervical ganglion. Brown, T.H., McAfee, D.A. Science (1982) [Pubmed]
  3. Atropine vs patching for treatment of amblyopia in children. Kushner, B.J. JAMA (2002) [Pubmed]
  4. Atropine and cardiac arrest. Jacobson, S. JAMA (1981) [Pubmed]
  5. Multiple-dose activated charcoal for treatment of yellow oleander poisoning: a single-blind, randomised, placebo-controlled trial. de Silva, H.A., Fonseka, M.M., Pathmeswaran, A., Alahakone, D.G., Ratnatilake, G.A., Gunatilake, S.B., Ranasinha, C.D., Lalloo, D.G., Aronson, J.K., de Silva, H.J. Lancet (2003) [Pubmed]
  6. Role of extrinsic and intrinsic nerves in the relationship between intestinal motility and transmural potential difference in the anesthetized ferret. Greenwood, B., Davison, J.S. Gastroenterology (1985) [Pubmed]
  7. Role of nitric oxide in esophageal peristalsis in the opossum. Yamato, S., Spechler, S.J., Goyal, R.K. Gastroenterology (1992) [Pubmed]
  8. Genetic dissection of theta rhythm heterogeneity in mice. Shin, J., Kim, D., Bianchi, R., Wong, R.K., Shin, H.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Sleep-induced apnea syndrome. Prevalence of cardiac arrhythmias and their reversal after tracheostomy. Tilkian, A.G., Guilleminault, C., Schroeder, J.S., Lehrman, K.L., Simmons, F.B., Dement, W.C. Am. J. Med. (1977) [Pubmed]
  10. Heroin addiction treated by atropine coma. Wandzel, L., Falicki, Z. The American journal of psychiatry. (1987) [Pubmed]
  11. Secretion of pancreatic polypeptide in patients with pancreatic endocrine tumors. Adrian, T.E., Uttenthal, L.O., Williams, S.J., Bloom, S.R. N. Engl. J. Med. (1986) [Pubmed]
  12. An animal model of myopia. Raviola, E., Wiesel, T.N. N. Engl. J. Med. (1985) [Pubmed]
  13. A crucial epileptogenic site in the deep prepiriform cortex. Piredda, S., Gale, K. Nature (1985) [Pubmed]
  14. Adenosine mediates a slow hyperpolarizing synaptic potential in autonomic neurones. Akasu, T., Shinnick-Gallagher, P., Gallagher, J.P. Nature (1984) [Pubmed]
  15. Vasoactive intestinal polypeptide and muscarinic receptors: supersensitivity induced by long-term atropine treatment. Hedlund, B., Abens, J., Bartfai, T. Science (1983) [Pubmed]
  16. Acute effect of diphenoxylate with atropine (Lomotil) in patients with chronic diarrhea and fecal incontinence. Harford, W.V., Krejs, G.J., Santa Ana, C.A., Fordtran, J.S. Gastroenterology (1980) [Pubmed]
  17. Aminophylline for bradyasystolic cardiac arrest refractory to atropine and epinephrine. Viskin, S., Belhassen, B., Roth, A., Reicher, M., Averbuch, M., Sheps, D., Shalabye, E., Laniado, S. Ann. Intern. Med. (1993) [Pubmed]
  18. Cardiac effects of acute ethanol ingestion unmasked by autonomic blockade. Child, J.S., Kovick, R.B., Levisman, J.A., Pearce, M.L. Circulation (1979) [Pubmed]
  19. Early closure of the tricuspid valve in a case of Ebstein's anomaly with type B Wolff-Parkinson-White Syndrome. Koiwaya, Y., Narabayashi, H., Koyanagi, S., Matsuguchi, H., Tanaka, S., Imaizumi, T., Kuroiwa, A., Nakamura, M., Hirata, T. Circulation (1979) [Pubmed]
  20. Acute transsynaptic regulation of tyrosine 3-monooxygenase activity in the rat superior cervical ganglion: evidence for both cholinergic and noncholinergic mechanisms. Ip, N.Y., Perlman, R.L., Zigmond, R.E. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  21. Substance P: a putative sensory transmitter in mammalian autonomic ganglia. Jiang, Z., Dun, N.J., Karczmar, A.G. Science (1982) [Pubmed]
  22. Mechanism of postarrhythmic renal vasoconstriction in the anesthetized dog. Katholi, R.E., Oparil, S., Urthaler, F., James, T.N. J. Clin. Invest. (1979) [Pubmed]
  23. Extracellular calcium and cholinergic stimulation of isolated canine parietal cells. Soll, A.H. J. Clin. Invest. (1981) [Pubmed]
  24. Acid-induced esophagobronchial-cardiac reflexes in humans. Wright, R.A., Miller, S.A., Corsello, B.F. Gastroenterology (1990) [Pubmed]
  25. Mechanism for the gastrokinetic action of domperidone. In vitro studies in guinea pigs. Takahashi, T., Kurosawa, S., Wiley, J.W., Owyang, C. Gastroenterology (1991) [Pubmed]
  26. Acetylcholine and bradykinin relax intrapulmonary arteries by acting on endothelial cells: role in lung vascular diseases. Chand, N., Altura, B.M. Science (1981) [Pubmed]
  27. Effect of cholecystokinin and the octapeptide of cholecystokinin on the feline sphincter of Oddi and gallbladder. Mechanisms of action. Behar, J., Biancani, P. J. Clin. Invest. (1980) [Pubmed]
  28. Direct muscarinic cholinergic inhibition of hepatic glucose production in humans. Boyle, P.J., Liggett, S.B., Shah, S.D., Cryer, P.E. J. Clin. Invest. (1988) [Pubmed]
  29. Vasoactive intestinal polypeptide mediates cholecystokinin-induced relaxation of the sphincter of Oddi. Wiley, J.W., O'Dorisio, T.M., Owyang, C. J. Clin. Invest. (1988) [Pubmed]
  30. Peptone stimulates CCK-releasing peptide secretion by activating intestinal submucosal cholinergic neurons. Li, Y., Owyang, C. J. Clin. Invest. (1996) [Pubmed]
  31. Action of gastrin in guinea pig oxyntic cells. Studies using quantitative cytochemistry. Heldsinger, A.A., Vinik, A.I. J. Clin. Invest. (1984) [Pubmed]
  32. In vivo regulation of secretion of bronchiolar Clara cells in rats. Massaro, G.D., Paris, M., Thet, L.A. J. Clin. Invest. (1979) [Pubmed]
  33. Effects of atropine and gastric inhibitory polypeptide on hepatic glucose uptake and insulin extraction in conscious dogs. Chap, Z., Ishida, T., Chou, J., Lewis, R., Hartley, C., Entman, M., Field, J.B. J. Clin. Invest. (1985) [Pubmed]
  34. Muscarinic cholinergic activation of mouse spleen cells cytotoxic to tumor cells in vitro. Lane, M.A. J. Natl. Cancer Inst. (1978) [Pubmed]
  35. Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells. Cheng, K., Zimniak, P., Raufman, J.P. Cancer Res. (2003) [Pubmed]
  36. Norepinephrine facilitates the development of the murine sweat response but is not essential. Tafari, A.T., Thomas, S.A., Palmiter, R.D. J. Neurosci. (1997) [Pubmed]
  37. Reciprocal regulation of ciliary neurotrophic factor receptors and acetylcholine receptors during synaptogenesis in embryonic chick atria. Wang, X., Halvorsen, S.W. J. Neurosci. (1998) [Pubmed]
  38. Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene. Shapiro, R.A., Scherer, N.M., Habecker, B.A., Subers, E.M., Nathanson, N.M. J. Biol. Chem. (1988) [Pubmed]
  39. Evidence that alpha 2-adrenergic pathways play a major role in growth hormone (GH) neuroregulation: alpha 2-adrenergic agonism counteracts the inhibitory effect of muscarinic cholinergic receptor blockade on the GH response to GH-releasing hormone, while alpha 2-adrenergic blockade diminishes the potentiating effect of increased cholinergic tone on such stimulation in normal men. Devesa, J., Diaz, M.J., Tresguerres, J.A., Arce, V., Lima, L. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  40. Gastrin injected into the lateral hypothalamus stimulates secretion of gastric acid in rats. Tepperman, B.L., Evered, M.D. Science (1980) [Pubmed]
  41. Nature of the vagal inhibitory innervation to the lower esophageal sphincter. Goyal, R.K., Rattan, S. J. Clin. Invest. (1975) [Pubmed]
  42. In vivo protein secretion by lung. Evidence for active secretion and interspecies differences. Massaro, D. J. Clin. Invest. (1975) [Pubmed]
  43. Trypsin suppression of pancreatic enzyme secretion. Differential effect on cholecystokinin release and the enteropancreatic reflex. Owyang, C., May, D., Louie, D.S. Gastroenterology (1986) [Pubmed]
  44. Plasma shedding by the canine oxyntic and pyloric glandular mucosa induced by topical action of acetylcholine. Effect of atropine and physostigmine. Davenport, H.W., Kauffman, G.L. Gastroenterology (1975) [Pubmed]
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