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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Normal long bone growth and development in type X collagen-null mice.

To investigate the role of type X collagen in skeletal development, we have generated type X collagen-null mice. Surprisingly, mice without type X collagen were viable and fertile and had no gross abnormalities in long bone growth or development. No differences were detected between the type X collagen-null mice and controls when growth plates of both newborn and 3-week old mice were examined by histology and by immunostaining for extracellular matrix components of bone including osteopontin, osteocalcin and type II collagen. Our results suggest that type X collagen is not required for long bone development. However, mice and humans with dominant acting type X collagen mutations have bone abnormalities, suggesting that only the presence of abnormal type X collagen can modify bone growth and development.[1]


  1. Normal long bone growth and development in type X collagen-null mice. Rosati, R., Horan, G.S., Pinero, G.J., Garofalo, S., Keene, D.R., Horton, W.A., Vuorio, E., de Crombrugghe, B., Behringer, R.R. Nat. Genet. (1994) [Pubmed]
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