Gene Review:
Spp1 - secreted phosphoprotein 1
Mus musculus
Synonyms:
2AR, 2ar, 44kDa bone phosphoprotein, AA960535, AI790405, ...
- Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. Bruemmer, D., Collins, A.R., Noh, G., Wang, W., Territo, M., Arias-Magallona, S., Fishbein, M.C., Blaschke, F., Kintscher, U., Graf, K., Law, R.E., Hsueh, W.A. J. Clin. Invest. (2003)
- Override of the osteoclast defect in osteopontin-deficient mice by metastatic tumor growth in the bone. Natasha, T., Kuhn, M., Kelly, O., Rittling, S.R. Am. J. Pathol. (2006)
- Extensive induction of important mediators of fibrosis and dystrophic calcification in desmin-deficient cardiomyopathy. Mavroidis, M., Capetanaki, Y. Am. J. Pathol. (2002)
- Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy and weight loss by modulating corticosteroid production. Wang, K.X., Shi, Y., Denhardt, D.T. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. Nomiyama, T., Perez-Tilve, D., Ogawa, D., Gizard, F., Zhao, Y., Heywood, E.B., Jones, K.L., Kawamori, R., Cassis, L.A., Tschöp, M.H., Bruemmer, D. J. Clin. Invest. (2007)
- Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R.T., Gao, Y.H., Inada, M., Sato, M., Okamoto, R., Kitamura, Y., Yoshiki, S., Kishimoto, T. Cell (1997)
- The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Chabas, D., Baranzini, S.E., Mitchell, D., Bernard, C.C., Rittling, S.R., Denhardt, D.T., Sobel, R.A., Lock, C., Karpuj, M., Pedotti, R., Heller, R., Oksenberg, J.R., Steinman, L. Science (2001)
- Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Ashkar, S., Weber, G.F., Panoutsakopoulou, V., Sanchirico, M.E., Jansson, M., Zawaideh, S., Rittling, S.R., Denhardt, D.T., Glimcher, M.J., Cantor, H. Science (2000)
- Identification of a ras-activated enhancer in the mouse osteopontin promoter and its interaction with a putative ETS-related transcription factor whose activity correlates with the metastatic potential of the cell. Guo, X., Zhang, Y.P., Mitchell, D.A., Denhardt, D.T., Chambers, A.F. Mol. Cell. Biol. (1995)
- Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Nilsson, S.K., Johnston, H.M., Whitty, G.A., Williams, B., Webb, R.J., Denhardt, D.T., Bertoncello, I., Bendall, L.J., Simmons, P.J., Haylock, D.N. Blood (2005)
- Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis. Craig, A.M., Smith, J.H., Denhardt, D.T. J. Biol. Chem. (1989)
- Altered bleomycin-induced lung fibrosis in osteopontin-deficient mice. Berman, J.S., Serlin, D., Li, X., Whitley, G., Hayes, J., Rishikof, D.C., Ricupero, D.A., Liaw, L., Goetschkes, M., O'Regan, A.W. Am. J. Physiol. Lung Cell Mol. Physiol. (2004)
- A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Eswarakumar, V.P., Horowitz, M.C., Locklin, R., Morriss-Kay, G.M., Lonai, P. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Secreted phosphoprotein 1 (osteopontin) is expressed by stromal macrophages in cyclic and pregnant endometrium of mice, but is induced by estrogen in luminal epithelium during conceptus attachment for implantation. White, F.J., Burghardt, R.C., Hu, J., Joyce, M.M., Spencer, T.E., Johnson, G.A. Reproduction (2006)
- Altered wound healing in mice lacking a functional osteopontin gene (spp1). Liaw, L., Birk, D.E., Ballas, C.B., Whitsitt, J.S., Davidson, J.M., Hogan, B.L. J. Clin. Invest. (1998)
- Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. Speer, M.Y., McKee, M.D., Guldberg, R.E., Liaw, L., Yang, H.Y., Tung, E., Karsenty, G., Giachelli, C.M. J. Exp. Med. (2002)
- Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation. Antonopoulou, I., Mavrogiannis, L.A., Wilkie, A.O., Morriss-Kay, G.M. J. Anat. (2004)
- Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression. Noda, M., Vogel, R.L., Craig, A.M., Prahl, J., DeLuca, H.F., Denhardt, D.T. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation. Rangaswami, H., Bulbule, A., Kundu, G.C. J. Biol. Chem. (2004)
- Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. Wai, P.Y., Mi, Z., Gao, C., Guo, H., Marroquin, C., Kuo, P.C. J. Biol. Chem. (2006)
- Parathyroid hormone-related protein regulates extracellular matrix gene expression in cementoblasts and inhibits cementoblast-mediated mineralization in vitro. Ouyang, H., McCauley, L.K., Berry, J.E., Saygin, N.E., Tokiyasu, Y., Somerman, M.J. J. Bone Miner. Res. (2000)
- Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive properties. Christensen, B., Kazanecki, C.C., Petersen, T.E., Rittling, S.R., Denhardt, D.T., Sørensen, E.S. J. Biol. Chem. (2007)
- Alterations in the expression of osteonectin, osteopontin and osteocalcin mRNAs during the development of skeletal tissues in vivo. Nakase, T., Takaoka, K., Hirakawa, K., Hirota, S., Takemura, T., Onoue, H., Takebayashi, K., Kitamura, Y., Nomura, S. Bone and mineral. (1994)
- Highly potent transcriptional activation by 16-ene derivatives of 1,25-dihydroxyvitamin D3. Lack of modulation by 9-cis-retinoic acid of response to 1,25-dihydroxyvitamin D3 or its derivatives. Ferrara, J., McCuaig, K., Hendy, G.N., Uskokovic, M., White, J.H. J. Biol. Chem. (1994)
- Increased proteinase expression during tumor progression of cell lines down-modulated for TIMP levels: a new transformation paradigm? [corrected]. Khokha, R., Waterhouse, P., Lala, P., Zimmer, M., Denhardt, D.T., Khokka, R. J. Cancer Res. Clin. Oncol. (1991)
- Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin. Gao, C., Guo, H., Mi, Z., Wai, P.Y., Kuo, P.C. J. Immunol. (2005)
- Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption. Hou, P., Troen, T., Ovejero, M.C., Kirkegaard, T., Andersen, T.L., Byrjalsen, I., Ferreras, M., Sato, T., Shapiro, S.D., Foged, N.T., Delaissé, J.M. Bone (2004)
- Expression and distribution of osteopontin and matrix metalloproteinase (MMP)-3 and -7 in mouse salivary glands. Muramatsu, T., Ohta, K., Asaka, M., Kizaki, H., Shimono, M. European journal of morphology. (2002)
- In vitro phosphorylation of mouse osteopontin expressed in E. coli. Ashkar, S., Teplow, D.B., Glimcher, M.J., Saavedra, R.A. Biochem. Biophys. Res. Commun. (1993)
- A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice. Aherrahrou, Z., Axtner, S.B., Kaczmarek, P.M., Jurat, A., Korff, S., Doehring, L.C., Weichenhan, D., Katus, H.A., Ivandic, B.T. Am. J. Pathol. (2004)
- The osteoblast transcription factor Runx2 is expressed in mammary epithelial cells and mediates osteopontin expression. Inman, C.K., Shore, P. J. Biol. Chem. (2003)
- The dioxin/aryl hydrocarbon receptor mediates downregulation of osteopontin gene expression in a mouse model of gastric tumourigenesis. Kuznetsov, N.V., Andersson, P., Gradin, K., Stein, P., Dieckmann, A., Pettersson, S., Hanberg, A., Poellinger, L. Oncogene (2005)
- Osteopontin regulation by inorganic phosphate is ERK1/2-, protein kinase C-, and proteasome-dependent. Beck, G.R., Knecht, N. J. Biol. Chem. (2003)
- Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. You, J., Reilly, G.C., Zhen, X., Yellowley, C.E., Chen, Q., Donahue, H.J., Jacobs, C.R. J. Biol. Chem. (2001)
- Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice. Matsui, Y., Iwasaki, N., Kon, S., Takahashi, D., Morimoto, J., Matsui, Y., Denhardt, D.T., Rittling, S., Minami, A., Uede, T. Arthritis Rheum. (2009)
- Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. Wang, D., Christensen, K., Chawla, K., Xiao, G., Krebsbach, P.H., Franceschi, R.T. J. Bone Miner. Res. (1999)
- Histone deacetylase inhibitors promote osteoblast maturation. Schroeder, T.M., Westendorf, J.J. J. Bone Miner. Res. (2005)
- Medium perfusion enhances osteogenesis by murine osteosarcoma cells in three-dimensional collagen sponges. Mueller, S.M., Mizuno, S., Gerstenfeld, L.C., Glowacki, J. J. Bone Miner. Res. (1999)