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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Idiopathic infantile hypercalcemia discovered in the newborn period.

We report a male newborn with typical clinical signs of idiopathic infantile hypercalcemia (IIH); that is, hypercalcemia, hypercalciuria, an elfin face and nephrocalcinosis without giving Vitamin D3 supplementation to the patient. He had been treated with a vitamin D-free, low calcium milk and rectal administration of exogenous calcitonin (elcatonin). The latter seemed to be more effective as a treatment for IIH. The serum calcium level came within the normal range and the serum 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) level decreased from 101.5 to 75.6 pg/mL with the treatments mentioned above. These results suggest that a high serum concentration of 1,25(OH)2D3 is part of the pathogenesis of IIH. However, we were not able to clarify the pathogenesis of the high serum concentration of 1,25(OH)2D3.[1]


  1. Idiopathic infantile hypercalcemia discovered in the newborn period. Shimizu, H., Kodama, S., Takeuchi, A., Matui, T., Nakao, H., Sakurai, T., Kobayashi, T. Acta paediatrica Japonica; Overseas edition. (1994) [Pubmed]
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