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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Hemifacial spasm and osteitis deformans.

PURPOSE/METHODS: A patient with osteitis deformans (Paget's disease) and hemifacial spasm underwent magnetic resonance tomographic angiography. Bone-modulating bisphosphonates and botulinum injection were administered to treat the hemifacial spasm. RESULTS/CONCLUSIONS: Computed tomography showed marked temporal bone overgrowth. Magnetic resonance tomographic angiography showed no vascular compression of the facial nerve root. The hemifacial spasm failed to resolve with intravenous pamidronate. Subsequent botulinum injection rendered the patient spasm free for 22 weeks. Further research on the use of bisphosphonates in the treatment of pagetoid hemifacial spasm is required.[1]


  1. Hemifacial spasm and osteitis deformans. Ing, E.B., Savino, P.J., Bosley, T.M., Sergott, R.C., Kelepouris, N. Am. J. Ophthalmol. (1995) [Pubmed]
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