Disease relevance of Temporal Bone

• We report a case of bilateral temporal bone anomalies in a child with symptomatic congenital cytomegalovirus infection and severe, bilateral sensorineural hearing loss identified at 3 months of age [1].
• The occurrence of an aggressive papillary middle ear/temporal bone tumor (APMET) and a benign adnexal papillary tumor of probable mesonephric origin (APMO) in a patient with von Hippel-Lindau disease (VHL) is reported [2].
• Cholesterol granuloma is thought to occur when pneumatized cells in the temporal bone become obstructed [3].
• Megakaryoblastic leukemia presenting as a temporal bone granulocytic sarcoma. Case report [4].
• The relationship of this developmental anomaly to the more commonly encountered midline encephalocele and isolated reports of temporal bone encephaloceles are discussed [5].

High impact information on Temporal Bone

• The auditory impairment in affected males was congenital, bilateral, profound, sensorineural, affecting all frequencies, and without evidence of radiographic abnormality of the temporal bone [6].
• The fibrocytes expressing mRNA and protein products of COCH are the very cell types which are either absent or markedly reduced and replaced by eosinophilic acellular material in temporal bone sections of individuals affected with DFNA9 [7].
• Treatment of mutants with colony-stimulating factor 1 (CSF-1), known to greatly reduce sclerosis in the axial skeleton, significantly improved hearing, stapedial form and tissue composition, and angiogenesis in the temporal bone [8].
• CONCLUSION: Coronal reformations from multi-detector row CT of the temporal bone are sufficient for the evaluation of SSCD [9].
• To investigate this inconsistency, the authors searched MR imaging files and clinical records to find patients who underwent MR imaging of the temporal bone (at 1.5 T) before and after intravenous administration of gadopentetate dimeglumine and who had bilateral clinically normal facial nerves [10].

Chemical compound and disease context of Temporal Bone

• The temporal bones were harvested and evaluated histologically using hemotoxylin and eosin staining for fibrosis [11].
• Radiology quiz case 2. Classic osteosarcoma of the temporal bone [12].
• Ten human temporal bones were obtained from cadavers and prepared in a formalin stain [13].
• In experimental animals, vitamin A deficiency and normal aging may result in temporal bone abnormalities; however, these bony changes have not been associated with sensorineural hearing loss [14].
• The temporal bone histopathological findings in a case of gentamicin sulfate-induced hearing loss and vertigo in an anephric patient undergoing hemodialysis are presented [15].

Biological context of Temporal Bone

• We describe a modified in situ hybridization protocol for localizing and quantifying fibronectin gene expression at the cellular level in paraffin sections of rat temporal bone [16].
• The active bone remodeling process in the knockout animals showed many similarities to otosclerosis seen in human temporal bones [17].
• A method for isolation and identification of both DNA and RNA sequences in archival human temporal bone specimens using the polymerase chain reaction technique has been developed [18].
• OBJECTIVE: To further characterize the phenotype of DFNA1 with comprehensive audiovestibular evaluation and computed tomography of the temporal bone [19].
• Our analysis of the expression of apoptosis-related proteins, markers of cell proliferation activity, and sex hormone receptors does not allow us to demonstrate that temporal bone and sinonasal inverted papilloma are different pathological entities [20].

Anatomical context of Temporal Bone

• The three-dimensional Fourier transform fast imaging with steady precession (FISP) technique was used to obtain high-resolution magnetic resonance (MR) images of the temporal bone region and to generate three-dimensional reconstructed images of the inner ear [21].
• OBJECT: Endolymphatic sac (ELS) tumors are low-grade malignancies of the temporal bone that are associated with von Hippel-Lindau (VHL) disease but can also occur sporadically [22].
• A study of 164 temporal bones with otosclerosis revealed stapes fixation in 123 [23].
• The histological analysis of the temporal bones revealed that the spiral ganglion cells in the basal turn of the cochlea where the magnitude of traumatic impact had been the least in our experimental condition were rescued in a statistically significant fashion in the compression with nimodipine treatment group [24].
• METHODS: Thirty-seven formalin-fixed cadaver temporal bones were studied after skeletonization of the facial nerve and tympanic annulus [25].

Associations of Temporal Bone with chemical compounds

• Experimental temporal bone histopathology in rats deprived of dietary retinol and maintained with supplemental retinoic acid [26].
• METHODS: Thirty-eight formalin-fixed cadaveric temporal bones were examined with 1-mm-thick contiguous parasagittal CT sections to determine the anatomy of the nerves in the internal auditory canal [27].
• In contrast to infections around polymer implants, infections around skin-penetrating titanium implants anchored in the temporal bone are often cured by local treatment [28].
• This result is in agreement with an independent assessment of the age of the temporal bone of this specimen (Tillier, AM [1982] Z. Morphol. Anthropol. 73:125-148) and is concordant with dental developmental ages given for modern humans [29].
• CONCLUSIONS: Selective laser sintering can result in accurate modeling of detailed anatomic structures in the human temporal bone [30].

Gene context of Temporal Bone

• Temporal bones were cleared to assess the overall otoconial deficit and to correlate structure and function for lm mice [31].
• Frozen sections of PLP-fixed, decalcified Long-Evans rat temporal bones were stained immunohistochemically for VR1 [32].
• Comparative analysis of phenotypic and genotypic data supports the hypothesis that the type of temporal bone anomaly may depend on the specific PDS allele variant present [33].
• Fibronectin immunoreactivity was examined in human temporal bone sections (6 months to 92 years old) [34].
• However, the subcellular localization of the Brn4 gene product shifts from strictly nuclear to perinuclear in those regions of the otic capsule that will cavitate to form acellular regions in the temporal bone, such as the scala tympani, scala vestibuli, and the internal auditory meatus [35].

Analytical, diagnostic and therapeutic context of Temporal Bone

• Non-metallic middle-ear prostheses, including a plastipore total ossicular replacement prosthesis (TORP) and partial ossicular replacement prosthesis (PORP), a Teflon loop stapes piston, and a Ceravital PORP were used to reconstruct the ossicular chain in formalin fixed cadaver temporal bones [36].
• Merging CAD data of an implantable hearing aid with CT data of the temporal bone in a VR environment was shown to be a feasible method of providing three-dimensional information for the presurgical determination of fit and mountability [37].
• A temporal bone study of insertion trauma and intracochlear position of cochlear implant electrodes. I: Comparison of Nucleus banded and Nucleus Contour electrodes [38].
• After each measurement, some of the animals were killed with an intracardiac perfusion of fixative, temporal bones were removed and were immunohistochemically examined for inducible nitric oxide synthase (iNOS/NOS II) [39].
• PATIENTS: Three patients of a consecutive series of 189; 1 man and 2 women who had received a bone-anchored, percutaneous, skin-penetrating, commercially pure titanium implant in the temporal bone, on which a transducer was mounted [40].

References