The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Temporal Bone

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Temporal Bone


High impact information on Temporal Bone

  • The auditory impairment in affected males was congenital, bilateral, profound, sensorineural, affecting all frequencies, and without evidence of radiographic abnormality of the temporal bone [6].
  • The fibrocytes expressing mRNA and protein products of COCH are the very cell types which are either absent or markedly reduced and replaced by eosinophilic acellular material in temporal bone sections of individuals affected with DFNA9 [7].
  • Treatment of mutants with colony-stimulating factor 1 (CSF-1), known to greatly reduce sclerosis in the axial skeleton, significantly improved hearing, stapedial form and tissue composition, and angiogenesis in the temporal bone [8].
  • CONCLUSION: Coronal reformations from multi-detector row CT of the temporal bone are sufficient for the evaluation of SSCD [9].
  • To investigate this inconsistency, the authors searched MR imaging files and clinical records to find patients who underwent MR imaging of the temporal bone (at 1.5 T) before and after intravenous administration of gadopentetate dimeglumine and who had bilateral clinically normal facial nerves [10].

Chemical compound and disease context of Temporal Bone


Biological context of Temporal Bone


Anatomical context of Temporal Bone


Associations of Temporal Bone with chemical compounds

  • Experimental temporal bone histopathology in rats deprived of dietary retinol and maintained with supplemental retinoic acid [26].
  • METHODS: Thirty-eight formalin-fixed cadaveric temporal bones were examined with 1-mm-thick contiguous parasagittal CT sections to determine the anatomy of the nerves in the internal auditory canal [27].
  • In contrast to infections around polymer implants, infections around skin-penetrating titanium implants anchored in the temporal bone are often cured by local treatment [28].
  • This result is in agreement with an independent assessment of the age of the temporal bone of this specimen (Tillier, AM [1982] Z. Morphol. Anthropol. 73:125-148) and is concordant with dental developmental ages given for modern humans [29].
  • CONCLUSIONS: Selective laser sintering can result in accurate modeling of detailed anatomic structures in the human temporal bone [30].

Gene context of Temporal Bone

  • Temporal bones were cleared to assess the overall otoconial deficit and to correlate structure and function for lm mice [31].
  • Frozen sections of PLP-fixed, decalcified Long-Evans rat temporal bones were stained immunohistochemically for VR1 [32].
  • Comparative analysis of phenotypic and genotypic data supports the hypothesis that the type of temporal bone anomaly may depend on the specific PDS allele variant present [33].
  • Fibronectin immunoreactivity was examined in human temporal bone sections (6 months to 92 years old) [34].
  • However, the subcellular localization of the Brn4 gene product shifts from strictly nuclear to perinuclear in those regions of the otic capsule that will cavitate to form acellular regions in the temporal bone, such as the scala tympani, scala vestibuli, and the internal auditory meatus [35].

Analytical, diagnostic and therapeutic context of Temporal Bone


  1. Mondini dysplasia and congenital cytomegalovirus infection. Bauman, N.M., Kirby-Keyser, L.J., Dolan, K.D., Wexler, D., Gantz, B.J., McCabe, B.F., Bale, J.F. J. Pediatr. (1994) [Pubmed]
  2. Aggressive papillary tumor of middle ear/temporal bone and adnexal papillary cystadenoma. Manifestations of von Hippel-Lindau disease. Gaffey, M.J., Mills, S.E., Boyd, J.C. Am. J. Surg. Pathol. (1994) [Pubmed]
  3. Cholesterol granuloma of the petrous apex and sphenoidal sinus: a case report. Gray, W.C., Salcman, M., Rao, K.C., Hafiz, M.A. Neurosurgery (1985) [Pubmed]
  4. Megakaryoblastic leukemia presenting as a temporal bone granulocytic sarcoma. Case report. Kaufman, B.A., Jones, L., Zutter, M.M., Park, T.S. J. Neurosurg. (1993) [Pubmed]
  5. Parietal intradiploic encephalocele. Case report. Kosnik, E.J., Meagher, J.N., Quenemoen, L.R. J. Neurosurg. (1976) [Pubmed]
  6. A new nonsyndromic X-linked sensorineural hearing impairment linked to Xp21.2. Lalwani, A.K., Brister, J.R., Fex, J., Grundfast, K.M., Pikus, A.T., Ploplis, B., San Agustin, T., Skarka, H., Wilcox, E.R. Am. J. Hum. Genet. (1994) [Pubmed]
  7. Inner ear localization of mRNA and protein products of COCH, mutated in the sensorineural deafness and vestibular disorder, DFNA9. Robertson, N.G., Resendes, B.L., Lin, J.S., Lee, C., Aster, J.C., Adams, J.C., Morton, C.C. Hum. Mol. Genet. (2001) [Pubmed]
  8. Auditory ossicle abnormalities and hearing loss in the toothless (osteopetrotic) mutation in the rat and their improvement after treatment with colony-stimulating factor-1. Aharinejad, S., Grossschmidt, K., Franz, P., Streicher, J., Nourani, F., MacKay, C.A., Firbas, W., Plenk, H., Marks, S.C. J. Bone Miner. Res. (1999) [Pubmed]
  9. Superior semicircular canal dehiscence: oblique reformatted CT images for diagnosis. Branstetter, B.F., Harrigal, C., Escott, E.J., Hirsch, B.E. Radiology. (2006) [Pubmed]
  10. Enhancement along the normal facial nerve in the facial canal: MR imaging and anatomic correlation. Gebarski, S.S., Telian, S.A., Niparko, J.K. Radiology. (1992) [Pubmed]
  11. The effect of gelfilm in the prevention of fibrosis in the middle ear of the animal model. McGhee, M.A., Dornhoffer, J.L. The American journal of otology. (1999) [Pubmed]
  12. Radiology quiz case 2. Classic osteosarcoma of the temporal bone. Sanal, H.T., Kilickesmez, O., Can, C. Arch. Otolaryngol. Head Neck Surg. (2005) [Pubmed]
  13. The topographical anatomy of the round window and related structures for the purpose of cochlear implant surgery. Paprocki, A., Biskup, B., Kozłowska, K., Kuniszyk, A., Bien, D., Niemczyk, K. Folia morphologica. (2004) [Pubmed]
  14. Modiolar microexostoses with neural impingement and hearing loss in guinea pigs. Strauss, M., Towfighi, J. American journal of otolaryngology. (1987) [Pubmed]
  15. Histopathological findings in clinical gentamicin ototoxicity. Keene, M., Hawke, M., Barber, H.O., Farkashidy, J. Archives of otolaryngology (Chicago, Ill. : 1960) (1982) [Pubmed]
  16. Improved resolution of fibronectin mRNA expression in the inner ear using laser scanning confocal microscopy. Woolf, N.K., Jaquish, D.V., Koehrn, F.J., Woods, V.L., Peterson, D.A. J. Histochem. Cytochem. (1996) [Pubmed]
  17. Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing loss. Zehnder, A.F., Kristiansen, A.G., Adams, J.C., Kujawa, S.G., Merchant, S.N., McKenna, M.J. Laryngoscope (2006) [Pubmed]
  18. Polymerase chain reaction amplification of a measles virus sequence from human temporal bone sections with active otosclerosis. McKenna, M.J., Kristiansen, A.G., Haines, J. The American journal of otology. (1996) [Pubmed]
  19. Further characterization of the DFNA1 audiovestibular phenotype. Lalwani, A.K., Jackler, R.K., Sweetow, R.W., Lynch, E.D., Raventós, H., Morrow, J., King, M.C., León, P.E. Arch. Otolaryngol. Head Neck Surg. (1998) [Pubmed]
  20. Temporal bone and sinonasal inverted papilloma: the same pathological entity? Blandamura, S., Marioni, G., de Filippis, C., Giacomelli, L., Segato, P., Staffieri, A. Arch. Otolaryngol. Head Neck Surg. (2003) [Pubmed]
  21. Three-dimensional reconstructed MR imaging of the inner ear. Tanioka, H., Shirakawa, T., Machida, T., Sasaki, Y. Radiology. (1991) [Pubmed]
  22. Endolymphatic sac tumors in patients with and without von Hippel-Lindau disease: the role of genetic mutation, von Hippel-Lindau protein, and hypoxia inducible factor-1alpha expression. Jensen, R.L., Gillespie, D., House, P., Layfield, L., Shelton, C. J. Neurosurg. (2004) [Pubmed]
  23. Histologic variants in otosclerosis. Schuknecht, H.F., Barber, W. Laryngoscope (1985) [Pubmed]
  24. Nimodipine ameliorates trauma-induced cochlear neuronal death. Sekiya, T., Yagihashi, A., Asano, K., Suzuki, S. Neurol. Res. (2002) [Pubmed]
  25. Relationship of the facial nerve to the tympanic annulus: a direct anatomic examination. Adad, B., Rasgon, B.M., Ackerson, L. Laryngoscope (1999) [Pubmed]
  26. Experimental temporal bone histopathology in rats deprived of dietary retinol and maintained with supplemental retinoic acid. Chole, R.A., Quick, C.A. J. Nutr. (1978) [Pubmed]
  27. Anatomy of the facial and vestibulocochlear nerves in the internal auditory canal. Rubinstein, D., Sandberg, E.J., Cajade-Law, A.G. AJNR. American journal of neuroradiology. (1996) [Pubmed]
  28. Cell surface characteristics of microbiological isolates from human percutaneous titanium implants in the head and neck. Holgers, K.M., Ljungh, A. Biomaterials (1999) [Pubmed]
  29. Age at death of the Neanderthal child from Devil's Tower, Gibraltar and the implications for studies of general growth and development in Neanderthals. Dean, M.C., Stringer, C.B., Bromage, T.G. Am. J. Phys. Anthropol. (1986) [Pubmed]
  30. Preliminary experience with selective laser sintering models of the human temporal bone. Levy, R.A., Guduri, S., Crawford, R.H. AJNR. American journal of neuroradiology. (1994) [Pubmed]
  31. Gravity receptor function in mice with graded otoconial deficiencies. Jones, S.M., Erway, L.C., Johnson, K.R., Yu, H., Jones, T.A. Hear. Res. (2004) [Pubmed]
  32. Type 1 vanilloid receptor expression by mammalian inner ear ganglion cells. Balaban, C.D., Zhou, J., Li, H.S. Hear. Res. (2003) [Pubmed]
  33. Pendred syndrome, DFNB4, and PDS/SLC26A4 identification of eight novel mutations and possible genotype-phenotype correlations. Campbell, C., Cucci, R.A., Prasad, S., Green, G.E., Edeal, J.B., Galer, C.E., Karniski, L.P., Sheffield, V.C., Smith, R.J. Hum. Mutat. (2001) [Pubmed]
  34. Fibronectin-like immunoreactivity of the basilar membrane of celloidin-embedded human temporal bone sections. Keithley, E.M., Tian, Q., Robins-Browne, R. Acta Otolaryngol. (1994) [Pubmed]
  35. Changes in the subcellular localization of the Brn4 gene product precede mesenchymal remodeling of the otic capsule. Phippard, D., Heydemann, A., Lechner, M., Lu, L., Lee, D., Kyin, T., Crenshaw, E.B. Hear. Res. (1998) [Pubmed]
  36. Computed tomographic evaluation of non-metallic middle-ear prostheses. Chakeres, D.W., Mattox, D.E. Investigative radiology. (1985) [Pubmed]
  37. Computer-aided surgical planning for implantation of hearing aids based on CT data in a VR environment. Dammann, F., Bode, A., Schwaderer, E., Schaich, M., Heuschmid, M., Maassen, M.M. Radiographics : a review publication of the Radiological Society of North America, Inc. (2001) [Pubmed]
  38. A temporal bone study of insertion trauma and intracochlear position of cochlear implant electrodes. I: Comparison of Nucleus banded and Nucleus Contour electrodes. Wardrop, P., Whinney, D., Rebscher, S.J., Roland, J.T., Luxford, W., Leake, P.A. Hear. Res. (2005) [Pubmed]
  39. Changes of the compound action potential (CAP) and the expression of inducible nitric oxide synthase (iNOS/NOS II) in the cochlea under the inflammatory condition(1). Watanabe, K., Hess, A., Zumeger, C., Stennert, E., Bloch, W., Addicks, K., Michel, O. Hear. Res. (2000) [Pubmed]
  40. Removal of titanium implants from the temporal bone: histologic findings. van der Pouw, C.T., Johansson, C.B., Mylanus, E.A., Albrektsson, T., Cremers, C.W. The American journal of otology. (1998) [Pubmed]
WikiGenes - Universities