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MeSH Review

Facial Nerve

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Disease relevance of Facial Nerve


Psychiatry related information on Facial Nerve


High impact information on Facial Nerve

  • Upon facial nerve transection, damaged CD200-deficient neurons elicited an accelerated microglial response [7].
  • Labeled cells were also observed in the major subdivisions of the amygdaloid complex, the olfactory bulb, the trochlear nerve nucleus, the dorsal tegmental region, the facial nerve nucleus, the nucleus of the spinal tract of the trigeminal nerve, and the spinal cord dorsal horn [8].
  • Seven days after facial nerve transection, both AChE mRNA and enzyme activity levels were markedly reduced in untreated and vehicle-treated facial motoneurons, suggesting positive regulation of motoneuron AChE expression by muscle-derived factors [9].
  • To evaluate whether endogenous CNTF, released after nerve injury from the cytosol of Schwann cells, supports motoneuron survival, we transected the facial nerve in 4-week-old pmn mice [10].
  • There was no significant difference in facial nerve outcome between intravenous and oral acyclovir treatment [11].

Chemical compound and disease context of Facial Nerve


Biological context of Facial Nerve


Anatomical context of Facial Nerve


Associations of Facial Nerve with chemical compounds

  • We have previously demonstrated that systemic administration of testosterone increases the rate of axonal regeneration following facial nerve crush in adult male hamsters [27].
  • Nimodipine accelerates axonal sprouting after surgical repair of rat facial nerve [28].
  • We report a 24-year-old woman with recurrent facial and lip swelling, lingua plicata, and peripheral facial-nerve palsy who benefited from a short course of high-dose i.v. methylprednisolone [29].
  • Most tracts had significantly higher activities than the cholinergic facial nerve root, consistent with the possibility that a component of aspartate aminotransferase activity might serve as a marker for neurons using glutamate and/or aspartate as neurotransmitter [30].
  • For identifying normal anatomic structures such as the facial nerve and the main duct, the administration of gadopentetate dimeglumine was helpful [31].

Gene context of Facial Nerve

  • Facial nerve lesion dramatically increased the number of surviving motoneurons in pmn mice [10].
  • Here we examined the regulation and function of p75NTR during regeneration after peripheral transection of the facial nerve of adult mice [32].
  • GDNF may therefore be useful in improving facial nerve regeneration in the clinic [33].
  • To test this hypothesis, we investigated adult mice constitutively deficient in the expression of TNC, TNR or both, using the facial nerve injury paradigm [34].
  • Opposite impacts of tenascin-C and tenascin-R deficiency in mice on the functional outcome of facial nerve repair [34].

Analytical, diagnostic and therapeutic context of Facial Nerve


  1. Practice parameter: Steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Grogan, P.M., Gronseth, G.S. Neurology (2001) [Pubmed]
  2. Dejerine-Sottas disease with sensorineural hearing loss, nystagmus, and peripheral facial nerve weakness: de novo dominant point mutation of the PMP22 gene. Ionasescu, V.V., Searby, C., Greenberg, S.A. J. Med. Genet. (1996) [Pubmed]
  3. The lesion causing continuous facial myokymia in multiple sclerosis. Jacobs, L., Kaba, S., Pullicino, P. Arch. Neurol. (1994) [Pubmed]
  4. Parasympathetic innervation of the meibomian glands in rats. LeDoux, M.S., Zhou, Q., Murphy, R.B., Greene, M.L., Ryan, P. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  5. Lattice corneal dystrophy associated with familial systemic amyloidosis (Meretoja's syndrome). Purcell, J.J., Rodrigues, M., Chishti, M.I., Riner, R.N., Dooley, J.M. Ophthalmology (1983) [Pubmed]
  6. Cell-based therapy of chronic degenerative diseases of the central nervous system. Pankratov, Y.V., Ivanov, A.I., Kolokoltsova, T.D., Nechayeva, Y.A., Radayeva, I.F., Korochkin, L.I., Revischin, A.V., Naumov, S.A., Khlusovi, I.A., Autenshlus, A.I. Adv. Exp. Med. Biol. (2003) [Pubmed]
  7. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Hoek, R.M., Ruuls, S.R., Murphy, C.A., Wright, G.J., Goddard, R., Zurawski, S.M., Blom, B., Homola, M.E., Streit, W.J., Brown, M.H., Barclay, A.N., Sedgwick, J.D. Science (2000) [Pubmed]
  8. Nervous system distribution of the serotonin 5-HT3 receptor mRNA. Tecott, L.H., Maricq, A.V., Julius, D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  9. Acetylcholinesterase gene expression in axotomized rat facial motoneurons is differentially regulated by neurotrophins: correlation with trkB and trkC mRNA levels and isoforms. Fernandes, K.J., Kobayashi, N.R., Jasmin, B.J., Tetzlaff, W. J. Neurosci. (1998) [Pubmed]
  10. Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice. Sendtner, M., Götz, R., Holtmann, B., Thoenen, H. J. Neurosci. (1997) [Pubmed]
  11. Treatment of Ramsay Hunt syndrome with acyclovir-prednisone: significance of early diagnosis and treatment. Murakami, S., Hato, N., Horiuchi, J., Honda, N., Gyo, K., Yanagihara, N. Ann. Neurol. (1997) [Pubmed]
  12. Hemifacial spasm: electrophysiological findings and the therapeutic effect of facial nerve block. Elmqvist, D., Toremalm, N.G., Elner, A., Mercke, U. Muscle Nerve (1982) [Pubmed]
  13. Aliphatic propargylamines as symptomatic and neuroprotective treatments for neurodegenerative diseases. Berry, M.D., Boulton, A.A. Neurotoxicology and teratology. (2002) [Pubmed]
  14. Gadolinium-enhanced magnetic resonance imaging in Bell's palsy. Schwaber, M.K., Larson, T.C., Zealear, D.L., Creasy, J. Laryngoscope (1990) [Pubmed]
  15. MRI of the facial nerve in idiopathic facial palsy. Saatçi, I., Sahintürk, F., Sennaroğlu, L., Boyvat, F., Gürsel, B., Besim, A. European radiology. (1996) [Pubmed]
  16. Cranial neuropathy associated with chlorinated solvents. Re: Facial nerve palsy after acute exposure to dichloromethane. Liss, G.M., House, R.A., Wills, M.C. Am. J. Ind. Med. (2006) [Pubmed]
  17. Induction of urokinase-type plasminogen activator in rat facial nucleus by axotomy of the facial nerve. Nakajima, K., Reddington, M., Kohsaka, S., Kreutzberg, G.W. J. Neurochem. (1996) [Pubmed]
  18. Distribution of the galectin-1 mRNA in the rat nervous system: its transient upregulation in rat facial motor neurons after facial nerve axotomy. Akazawa, C., Nakamura, Y., Sango, K., Horie, H., Kohsaka, S. Neuroscience (2004) [Pubmed]
  19. Gonadal steroid regulation of hamster facial nerve regeneration: effects of dihydrotestosterone and estradiol. Tanzer, L., Jones, K.J. Exp. Neurol. (1997) [Pubmed]
  20. PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis. van der Zwaag, B., Hellemons, A.J., Leenders, W.P., Burbach, J.P., Brunner, H.G., Padberg, G.W., Van Bokhoven, H. Dev. Dyn. (2002) [Pubmed]
  21. Effect of facial nerve transection on acetylcholinesterase, choline acetyltransferase and [3H]quinuclidinyl benzilate binding in rat facial nuclei. Hoover, D.B., Hancock, J.C. Neuroscience (1985) [Pubmed]
  22. Rapid induction of the major embryonic alpha-tubulin mRNA, T alpha 1, during nerve regeneration in adult rats. Miller, F.D., Tetzlaff, W., Bisby, M.A., Fawcett, J.W., Milner, R.J. J. Neurosci. (1989) [Pubmed]
  23. Facial nerve neuromas: radiologic evaluation. Latack, J.T., Gabrielsen, T.O., Knake, J.E., Kemink, J.L., Graham, M.D., Gebarski, S.S., Yang, P.J. Radiology. (1983) [Pubmed]
  24. Calcitonin gene-related peptide in rat salivary glands: neuronal localization, depletion upon nerve stimulation, and effects on salivation in relation to substance P. Ekström, J., Ekman, R., Håkanson, R., Sjögren, S., Sundler, F. Neuroscience (1988) [Pubmed]
  25. Interleukin-6 (IL6) and cellular response to facial nerve injury: effects on lymphocyte recruitment, early microglial activation and axonal outgrowth in IL6-deficient mice. Galiano, M., Liu, Z.Q., Kalla, R., Bohatschek, M., Koppius, A., Gschwendtner, A., Xu, S., Werner, A., Kloss, C.U., Jones, L.L., Bluethmann, H., Raivich, G. Eur. J. Neurosci. (2001) [Pubmed]
  26. Three-dimensional analysis of vestibular efferent neurons innervating semicircular canals of the gerbil. Purcell, I.M., Perachio, A.A. J. Neurophysiol. (1997) [Pubmed]
  27. Androgenic regulation of tubulin gene expression in axotomized hamster facial motoneurons. Jones, K.J., Oblinger, M.M. J. Neurosci. (1994) [Pubmed]
  28. Nimodipine accelerates axonal sprouting after surgical repair of rat facial nerve. Angelov, D.N., Neiss, W.F., Streppel, M., Andermahr, J., Mader, K., Stennert, E. J. Neurosci. (1996) [Pubmed]
  29. Melkersson-Rosenthal syndrome treated by methylprednisolone. Kesler, A., Vainstein, G., Gadoth, N. Neurology (1998) [Pubmed]
  30. Aspartate aminotransferase activity in fiber tracts of the rat brain. Godfrey, D.A., Bowers, M., Johnson, B.A., Ross, C.D. J. Neurochem. (1984) [Pubmed]
  31. Parotid gland: plain and gadolinium-enhanced MR imaging. Vogl, T.J., Dresel, S.H., Späth, M., Grevers, G., Wilimzig, C., Schedel, H.K., Lissner, J. Radiology. (1990) [Pubmed]
  32. Regulation, cellular localization, and function of the p75 neurotrophin receptor (p75NTR) during the regeneration of facial motoneurons. Gschwendtner, A., Liu, Z., Hucho, T., Bohatschek, M., Kalla, R., Dechant, G., Raivich, G. Mol. Cell. Neurosci. (2003) [Pubmed]
  33. Glial cell line-derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat. Barras, F.M., Pasche, P., Bouche, N., Aebischer, P., Zurn, A.D. J. Neurosci. Res. (2002) [Pubmed]
  34. Opposite impacts of tenascin-C and tenascin-R deficiency in mice on the functional outcome of facial nerve repair. Guntinas-Lichius, O., Angelov, D.N., Morellini, F., Lenzen, M., Skouras, E., Schachner, M., Irintchev, A. Eur. J. Neurosci. (2005) [Pubmed]
  35. Distribution of alpha1A adrenergic receptor mRNA in the rat brain visualized by in situ hybridization. Domyancic, A.V., Morilak, D.A. J. Comp. Neurol. (1997) [Pubmed]
  36. Differential regulation of motor neuron survival and choline acetyltransferase expression following axotomy. Kou, S.Y., Chiu, A.Y., Patterson, P.H. J. Neurobiol. (1995) [Pubmed]
  37. Lacrimal preganglionic neurons form a subdivision of the superior salivatory nucleus of rat: transneuronal labelling by pseudorabies virus. Tóth, I.E., Boldogkoi, Z., Medveczky, I., Palkovits, M. J. Auton. Nerv. Syst. (1999) [Pubmed]
  38. Bell's palsy: surgery based upon prognostic indicators and results. May, M., Blumenthal, F., Taylor, F.H. Laryngoscope (1981) [Pubmed]
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