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Frith, C.D. et al.

Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome.

5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve the patient's mood or reduce self-mutilation.[1]

References

Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome. Frith, C.D., Johnston, E.C., Joseph, M.H., Powell, R.J., Watts, R.W. J. Neurol. Neurosurg. Psychiatr. (1976) [Pubmed]

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