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Chemical Compound Review

oxytryptophan     2-amino-3-(5-hydroxy-1H- indol-3...

Synonyms: Serotonyl, Telesol, Levotinine, Oxyfan, DL-Pretonine, ...
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Disease relevance of oxitriptan


Psychiatry related information on oxitriptan


High impact information on oxitriptan


Chemical compound and disease context of oxitriptan


Biological context of oxitriptan


Anatomical context of oxitriptan


Associations of oxitriptan with other chemical compounds


Gene context of oxitriptan

  • Effect of 1-5 hydroxytryptophan infusion on growth hormone and prolactin secretion in man [32].
  • Injection of the antagonists did not alter the 5-hydroxytryptophan-induced increase in plasma PRL or the increase associated with acute ether stress or acute suckling stimuli, suggesting that OXY is not a major component involved in the neuroendocrine mechanisms responsible for those particular increases [33].
  • Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines [34].
  • 5-HT2 receptor-mediated head twitch behaviour induced by precursor loading with 5-HTP was unaffected by TVX Q 7821 (10 mg/kg) pretreatment 75 min earlier, but the head-twitch induced by the agonist 5-methoxy-N,N-dimethyltryptamine was enhanced by prior treatment with TVX Q 7821 [35].
  • Depletion of 5-HT with reserpine markedly reduced the citalopram-induced decrease of 5-HTP but not that evoked by the 5-HT1A receptor agonist 8-OH-DPAT, which indicates that the presence of endogenous 5-HT is necessary for full effect of citalopram [36].

Analytical, diagnostic and therapeutic context of oxitriptan


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