Disease relevance of oxitriptan

• Myoclonus in the young after 5-hydroxytryptophan [1].
• Administration of 5-hydroxytryptophan to rats treated with para-chlorophenylalanine partially alleviated the hyperventilation [2].
• Four of the 23 patients with the carcinoid syndrome (15%) had markedly elevated excretion of 5-hydroxytryptophan [3].
• Letter: L-dopa and 5-hydroxytryptophan therapy in phenylketonuria with normal phenylalanine-hydroxylase activity [4].
• Spectral enhancement of proteins: biological incorporation and fluorescence characterization of 5-hydroxytryptophan in bacteriophage lambda cI repressor [5].

Psychiatry related information on oxitriptan

• Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. I. Enhanced response in depression and mania [6].
• Neuroendocrine response to 5-hydroxytryptophan in seasonal affective disorder [7].
• METHODS: A serotonergic precursor, 5-hydroxy-L-tryptophan (L-5HTP) (oxitriptan) (0.8 mg/kg), was administered through an indwelling catheter to 36 children at high risk of MDD (with high family loading for MDD), 31 children with MDD, and 23 low-risk normal controls (with low family loading for mood disorders and no history of psychopathology) [8].
• This statement is based on the following findings: (i) 5-HTP can abolish or alleviate the depressive syndrome or some of its elements [9].
• Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan [10].

High impact information on oxitriptan

• A scleroderma-like illness developed in a patient treated with L-5 hydroxytryptophan (L-5HTP) and carbidopa for intention myoclonus [11].
• Neuroendocrine response to 5-hydroxy-L-tryptophan in prepubertal children at high risk of major depressive disorder [8].
• There was a sex-by-diagnosis interaction in prolactin response to L-5-hydroxytryptophan and, on examination, the prolactin hypersecretion was seen in depressed girls but not in depressed boys compared with same-sex controls [12].
• No differences in the melatonin level, growth hormone level, blood pressure, or pulse rate and no side effects were noted between patients and controls in the two study conditions; the timing of basal and 5-hydroxytryptophan-stimulated hormonal secretions was similar for both groups [7].
• Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressants and lithium carbonate [13].

Chemical compound and disease context of oxitriptan

• Reports of myoclonus developing after anoxic brain injury, and its response to treatment with the serotonin precursor 5-hydroxytryptophan (5-HTP), drew special attention [14].
• We have evaluated the usefulness of positron emission tomography (PET) with carbon-11-labeled 5-HTP in the diagnosis and treatment follow-up evaluation of patients with neuroendocrine tumors [15].
• Two patients are reported with palatal myoclonus, progressive ataxia, and dysarthria, unresponsive to treatment with trihexyphenidyl or L-5-hydroxytryptophan [16].
• (in press), lambda cI repressor spectrally enhanced by 5-hydroxytryptophan (5-OHTrp), expressed in vivo using an Escherichia coli tryptophan auxotroph, exhibits dimer formation and DNA binding properties identical with those of the wild-type repressor [17].
• Plasma 5-HIAA, but not 5-HTP was detectable in 8 of 17 patients with carcinoid tumors [18].

Biological context of oxitriptan

• Histamine and 5-hydroxytryptophan do not significantly interact with the system (IC50 greater than 1 mM) [19].
• Previous observations have shown that oral administration of 5-hydroxytryptophan (5-HTP) without dietary prescriptions causes anorexia, decreased food intake, and weight loss in obese subjects [10].
• Effect of 5-hydroxytryptophan on H-reflex recovery curves in normal subjects and patients with affective disorders [20].
• This expressed enzyme catalyzed the decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA), L-5-hydroxytryptophan (L-5-HTP) and L-threo-3,4-dihydroxyphenylserine [21].
• To saturate tryptophan hydroxylation with amino acid substrate, rats were administered a high dose of tryptophan 1 h prior to analysis of brain tryptophan, 5-hydroxytryptophan, serotonin, and 5-hydroxyindoleacetic acid [22].

Anatomical context of oxitriptan

• Formation of 5-hydroxykynurenine and 5-hydroxykynurenamine from 5-hydroxytryptophan in rabbit small intestine [23].
• Specific antagonism of enteric neural serotonin receptors by dipeptides of 5-hydroxytryptophan: evidence that serotonin is a mediator of slow synaptic excitation in the myenteric plexus [24].
• Levels of the precursor amino acid tryptophan were increased in thalamus (p < 0.01) and globus pallidus (p < 0.01); in both patient groups levels of 5-hydroxytryptophan and the tryptamine metabolite indoleacetic acid were increased in all brain areas studied [25].
• Liver metastases, as well as lymph node, pleural, and skeletal metastases, showed enhanced 5-HTP uptake and PET could detect more lesions than CT in 10 patients and equal numbers in the others [15].
• In preliminary electrophysiological experiments on microcultures containing single sympathetic principal neurons and cardiac myocytes, a nonadrenergic excitatory (NAE) interaction was sometimes obtained after exposing the neurons to 100 microM 5-hydroxytryptophan [26].

Associations of oxitriptan with other chemical compounds

• Calcium binding to chicken recombinant skeletal muscle TnC (TnC) and its mutants containing tryptophan (F29W), 5-hydroxytryptophan (F29HW), or 7-azatryptophan (F29ZW) at position 29 was measured by flow dialysis and by fluorescence [27].
• The ESR spectra of the free radicals formed by the autoxidation of serotonin, 5-hydroxyindole, and 5-hydroxytryptophan in 1 N NaOH are presented [28].
• The authors studied the effects of oral loading with 5-HTP on REM fragmentation in a group of alcoholics who were abstinent following acute ethanol withdrawal [29].
• Chronic administration of cortisol succinate (12.5 mg per kilogram per day) to guinea pigs suppressed jumping behavior induced by 1-5 hydroxytryptophan and abolished diurnal threshold variations of this behavior [30].
• Increased levels of 5-hydroxytryptophan (5-HTP) indicate that carbidopa directly inhibits 5-HTP decarboxylation, thus limiting 5-HT production [31].

Gene context of oxitriptan

• Effect of 1-5 hydroxytryptophan infusion on growth hormone and prolactin secretion in man [32].
• Injection of the antagonists did not alter the 5-hydroxytryptophan-induced increase in plasma PRL or the increase associated with acute ether stress or acute suckling stimuli, suggesting that OXY is not a major component involved in the neuroendocrine mechanisms responsible for those particular increases [33].
• Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines [34].
• 5-HT2 receptor-mediated head twitch behaviour induced by precursor loading with 5-HTP was unaffected by TVX Q 7821 (10 mg/kg) pretreatment 75 min earlier, but the head-twitch induced by the agonist 5-methoxy-N,N-dimethyltryptamine was enhanced by prior treatment with TVX Q 7821 [35].
• Depletion of 5-HT with reserpine markedly reduced the citalopram-induced decrease of 5-HTP but not that evoked by the 5-HT1A receptor agonist 8-OH-DPAT, which indicates that the presence of endogenous 5-HT is necessary for full effect of citalopram [36].

Analytical, diagnostic and therapeutic context of oxitriptan

• Response suppression in rats after bilateral microinjection of 5-hydroxytryptophan in lateral hypothalamus [37].
• Myoclonus was induced in guinea pigs in a dose-dependent manner by intraperitoneal injection of L-5-hydroxytryptophan (L-5-HTP) [38].
• These data support the important role previously assigned to central 5-HT mechanisms in the 5-HTP animal model of depression [37].
• Our objective was to investigate whether whole-body (WB) positron emission tomography (PET) with (11)C-5-hydroxytryptophan (5-HTP) can be used as a universal imaging technique for NETs and to compare this technique with established imaging methods [39].
• Determination of 5-hydroxytryptophan in plasma by high-performance liquid chromatography and fluorometric detection after phthaldialdehyde reaction [40].

References