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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers.

Human neutrophil-type (MMP-8) and fibroblast-type (MMP-1) interstitial collagenase, and their inhibition by tetracyclines in saliva from patients with recurrent aphthous ulcers (RAU) or aphthae, were studied by means of sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and enzymological analyses. In the salivary specimens obtained from patients with aphthae, collagenase was found in endogenously active form and was predominantly of MMP-8 type. Topical rinsing treatment with chlortetracycline (Aureomycin) alleviated the discomfort caused by the lesions but did not reduce salivary collagenase amounts; however in vitro, doxycycline inhibited salivary collagenase totally.[1]

References

  1. Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers. Häyrinen-Immonen, R., Sorsa, T., Pettilä, J., Konttinen, Y.T., Teronen, O., Malmström, M. J. Oral Pathol. Med. (1994) [Pubmed]
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