The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Antinociception and side effects of liposome-encapsulated alfentanil after spinal delivery in rats.

We investigated the spinal antinociceptive and supraspinally mediated side effects of intrathecal (IT) alfentanil after delivery in saline or when encapsulated in liposomes of different lipid constituencies in rats. Rats prepared with chronic IT catheters received IT injections of alfentanil (1, 3, 10, 30, or 50 micrograms) prepared in either saline or in one of three liposome formulations (dipalmitoyl phosphatidyl choline [DPPC], DPPC containing 20% by weight of dipalmitoyl phosphatidyl glycerol [DPPC-DPPG], or DPPC containing 20 weight percent of cholesterol [DPPC-CHOL]). Antinociception was measured by hot-plate (HP) test (52.5 degrees C). In separate groups of halothane-anesthetized rats, plasma alfentanil concentrations were measured (2-120 min) after 50 micrograms IT alfentanil given in either saline or liposomes. Antinociception was measured by tail withdrawal upon its immersion in water 52.5 degrees C. Supraspinal side effects of the drug were tested by measuring catalepsy and the eye blink evoked by touching the cornea. IT alfentanil in saline produced a dose-dependent increase in the HP response latency and this effect was accompanied by a similar dose-dependent increase in the incidence of catalepsy and blockade of corneal responses, indicating a rapid supraspinal redistribution. The HP dose-response curve for IT alfentanil delivered in liposomes was shifted slightly to the right, as compared to saline vehicle, but liposome encapsulation totally abolished the side effects that were otherwise observed at the highest IT alfentanil dose.(ABSTRACT TRUNCATED AT 250 WORDS)[1]


  1. Antinociception and side effects of liposome-encapsulated alfentanil after spinal delivery in rats. Wallace, M.S., Yanez, A.M., Ho, R.J., Shen, D.D., Yaksh, T.L. Anesth. Analg. (1994) [Pubmed]
WikiGenes - Universities