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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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T cell tumours of disparate phenotype in mice transgenic for Rbtn-2.

RBTN2 is a LIM domain protein which can be activated by the translocation t(11;14)(p13;q11) in childhood T cell acute leukaemia. Transgenic mice were examined in which rbtn2 protein is expressed in the T cell lineage. An average of 72% of these mice developed T cell tumours before 18 months of age, compared with 9% in transgenic mice expressing the related gene Rbtn-1. Rbtn2-induced tumours first appeared at 5 months of age and were clonal. They displayed a range of phenotypes, the most notable being CD3/CD45R double-positive cells. Tumours expressing either T cell receptor alpha/beta or gamma/delta heterodimers were found. Thus rbtn2 can promote tumours within a range of T cell types and maturities. The latency period before tumour development indicates that secondary events must occur before the onset of overt malignancy.[1]

References

  1. T cell tumours of disparate phenotype in mice transgenic for Rbtn-2. Larson, R.C., Fisch, P., Larson, T.A., Lavenir, I., Langford, T., King, G., Rabbitts, T.H. Oncogene (1994) [Pubmed]
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