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Gene Review

Lmo2  -  LIM domain only 2

Mus musculus

Synonyms: Cysteine-rich protein TTG-2, LIM domain only protein 2, LMO-2, Rbtn-2, Rbtn2, ...
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Disease relevance of Lmo2


High impact information on Lmo2


Biological context of Lmo2


Anatomical context of Lmo2

  • The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis [1].
  • These results show that Lmo2 is not needed for de novo capillary formation from mesoderm but is necessary for angiogenic remodeling of the existing capillary network into mature vasculature [7].
  • Moreover, Lmo2-null ES cells do not contribute to endothelial cells of large vessel walls of surviving chimeric mice after embryonic day 10 [7].
  • Lmo2 is expressed in vascular endothelium, and Lmo2-null ES cells contributed to the capillary network normally until around embryonic day 9 [7].
  • To further understand the mechanisms involved in the generation of definitive hemopoietic stem cells, we analysed the expression of the hemopoietic-related transcription factors Lmo2 and GATA-3 during the early steps of mouse development (7-12 dpc), with a particular emphasis on intraembryonic hemogenic sites [11].

Other interactions of Lmo2

  • These findings show that Lmo1, Lmo2, and Lmo3 continue to be expressed in the adult mammalian CNS in a cell type-specific manner, are differentially regulated by neuronal activity, and may thus be involved in cell phenotype-specific regulatory functions [12].
  • This disruption of hematopoiesis probably occurs because interaction of Lmo2 protein with factors such as Tal1/Scl is precluded [1].
  • Tumour development was compared in Lmo2 transgenic mice in the presence or absence of the Rag1 gene [13].
  • However, after this time, marked disorganization of the vascular system was observed in those chimeric mice that have a high contribution of Lmo2-null ES cells [7].


  1. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Yamada, Y., Warren, A.J., Dobson, C., Forster, A., Pannell, R., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target. Yamada, Y., Pannell, R., Forster, A., Rabbitts, T.H. Oncogene (2002) [Pubmed]
  3. p53 deficiency and misexpression of protein kinase CK2alpha collaborate in the development of thymic lymphomas in mice. Landesman-Bollag, E., Channavajhala, P.L., Cardiff, R.D., Seldin, D.C. Oncogene (1998) [Pubmed]
  4. Expression of the proto-oncogene rhombotin-2 is identical to the acute phase response protein metallothionein, suggesting multiple functions. Neale, G.A., Mao, S., Parham, D.M., Murti, K.G., Goorha, R.M. Cell Growth Differ. (1995) [Pubmed]
  5. The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. Grütz, G.G., Bucher, K., Lavenir, I., Larson, T., Larson, R., Rabbitts, T.H. EMBO J. (1998) [Pubmed]
  6. Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. Larson, R.C., Lavenir, I., Larson, T.A., Baer, R., Warren, A.J., Wadman, I., Nottage, K., Rabbitts, T.H. EMBO J. (1996) [Pubmed]
  7. The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice. Yamada, Y., Pannell, R., Forster, A., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  8. The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. McCormack, M.P., Forster, A., Drynan, L., Pannell, R., Rabbitts, T.H. Mol. Cell. Biol. (2003) [Pubmed]
  9. T cell tumours of disparate phenotype in mice transgenic for Rbtn-2. Larson, R.C., Fisch, P., Larson, T.A., Lavenir, I., Langford, T., King, G., Rabbitts, T.H. Oncogene (1994) [Pubmed]
  10. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Boehm, T., Foroni, L., Kaneko, Y., Perutz, M.F., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  11. Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites. Manaia, A., Lemarchandel, V., Klaine, M., Max-Audit, I., Romeo, P., Dieterlen-Lièvre, F., Godin, I. Development (2000) [Pubmed]
  12. Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity. Hinks, G.L., Shah, B., French, S.J., Campos, L.S., Staley, K., Hughes, J., Sofroniew, M.V. J. Neurosci. (1997) [Pubmed]
  13. T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity. Drynan, L.F., Hamilton, T.L., Rabbitts, T.H. Oncogene (2001) [Pubmed]
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