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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae.

We isolated a novel human cDNA, termed hCDC10, whose predicted product showed a high degree of homology to the CDC10 protein of Saccharomyces cerevisiae. This cDNA contained an open reading frame of 1254 nucleotides encoding 418 amino acids, which included a GTP-binding motif, GX4GKS--DX2G--KXD. The predicted peptide sequence also revealed partial amino-acid identity (40-50%) with Diff 6 in Drosophila and with H5 in mouse. Each of these sequence homologues, including Saccharomyces cerevisiae CDC10, contains the GTP-binding motif. Northern blot analyses indicated that the hCDC10 gene is expressed ubiquitously in normal tissues.[1]

References

  1. Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. Nakatsuru, S., Sudo, K., Nakamura, Y. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
 
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