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Gene Review

SEPT7  -  septin 7

Homo sapiens

Synonyms: CDC10, CDC10 protein homolog, CDC3, NBLA02942, SEPT7A, ...
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Disease relevance of SEPT7


High impact information on SEPT7


Biological context of SEPT7

  • We examined the gene expression of V-1, a novel soluble protein with the cdc10/SWI6 motif, in pseudopregnant rat ovaries [8].
  • The three loci, called CDC3, EF3, and HIS3, were chosen because they are on different chromosomes so as to improve the chances of finding polymorphisms [9].
  • The gene transcription unit, composed of 13 exons, encodes a potential 417/446 amino acid GTP-binding protein, highly similar to human CDC10 [10].

Analytical, diagnostic and therapeutic context of SEPT7


  1. The impact of oral examination on the Centers for Disease Control classification of subjects with human immunodeficiency virus infection. Schulten, E.A., ten Kate, R.W., van der Waal, I. Arch. Intern. Med. (1990) [Pubmed]
  2. The high level of hCDC10 gene expression in neuroblastoma may be associated with favorable characteristics of the tumor. Nagata, T., Takahashi, Y., Asai, S., Ishii, Y., Mugishima, H., Suzuki, T., Chin, M., Harada, K., Koshinaga, S., Ishikawa, K. J. Surg. Res. (2000) [Pubmed]
  3. Screening for HIV-associated distal-symmetric polyneuropathy in CDC-classification stages 1, 2, and 3. Husstedt, I.W., Evers, S., Reichelt, D., Grotemeyer, K.H., Kammer-Suhr, B., Böckenholt, S., Heese, C. Acta neurologica Scandinavica. (2000) [Pubmed]
  4. Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Hsu, S.C., Hazuka, C.D., Roth, R., Foletti, D.L., Heuser, J., Scheller, R.H. Neuron (1998) [Pubmed]
  5. Structural analysis of septin 2, 6, and 7 complexes. Low, C., Macara, I.G. J. Biol. Chem. (2006) [Pubmed]
  6. Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. Nagata, K., Asano, T., Nozawa, Y., Inagaki, M. J. Biol. Chem. (2004) [Pubmed]
  7. Expression profiling the human septin gene family. Hall, P.A., Jung, K., Hillan, K.J., Russell, S.E. J. Pathol. (2005) [Pubmed]
  8. Changes in the gene expression of a protein with the cdc10/SWI6 motif, V-1, during rat follicular development and corpus luteum formation. Song, S.Y., Asakai, R., Kenmotsu, N., Taoka, M., Isobe, T., Yamakuni, T. Endocrinology (1996) [Pubmed]
  9. Analysis of microsatellite markers of Candida albicans used for rapid typing. Botterel, F., Desterke, C., Costa, C., Bretagne, S. J. Clin. Microbiol. (2001) [Pubmed]
  10. Sequence of murine CDC10 cDNA, gene organization and expression analysis. Soulier, S., Vilotte, J.L. Biochim. Biophys. Acta (1998) [Pubmed]
  11. Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. Nakatsuru, S., Sudo, K., Nakamura, Y. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  12. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Ohno, H., Takimoto, G., McKeithan, T.W. Cell (1990) [Pubmed]
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