Disease relevance of SEPT7

• Twelve patients (55%) initially classified as CDC 2, and 4 patients (36%) initially classified as CDC 3 had to be reallocated to CDC group 4 due to the presence of oral candidiasis, hairy leukoplakia, or oral Kaposi's sarcoma [1].
• The high level of hCDC10 gene expression in neuroblastoma may be associated with favorable characteristics of the tumor [2].
• Significant correlation between neurophysiological changes and CDC4(+)-cells and beta-microglobuline were detected for stage CDC 3 C. CONCLUSION: Results show stage related prevalence of distal symmetric polyneuropathy already in early stages [3].

High impact information on SEPT7

• One of the septins, CDC10, displays broad subcellular and tissue distributions and is found in postmitotic neurons as well as dividing cells [4].
• Using fluorescence resonance energy transfer, size exclusion chromatography, and multi-angle light scattering techniques, we have characterized the conformation of a complex of filamentous human septins, Sept2, Sept6, and Sept7 [5].
• Immunofluorescence studies revealed co-localization of Sept7, Sept9b, and Sept11 along stress fibers in REF52 cells [6].
• A novel septin, SEPT13, has been identified and is shown to be related to SEPT7 [7].
• Changes in the gene expression of a protein with the cdc10/SWI6 motif, V-1, during rat follicular development and corpus luteum formation [8].

Biological context of SEPT7

• We examined the gene expression of V-1, a novel soluble protein with the cdc10/SWI6 motif, in pseudopregnant rat ovaries [8].
• The three loci, called CDC3, EF3, and HIS3, were chosen because they are on different chromosomes so as to improve the chances of finding polymorphisms [9].
• The gene transcription unit, composed of 13 exons, encodes a potential 417/446 amino acid GTP-binding protein, highly similar to human CDC10 [10].

Analytical, diagnostic and therapeutic context of SEPT7

• Northern blot analyses indicated that the hCDC10 gene is expressed ubiquitously in normal tissues [11].
• Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae [11].
• Sequence analysis of the human bcl-3 gene predicts a protein containing seven tandem copies of the SWI6/cdc10 motif [12].

References