- ICV injection of the serotonin 5-HT1B agonist CP-93,129 increases the secretion of ACTH, prolactin, and renin and increases blood pressure by nonserotonergic mechanisms. Van de Kar, L.D., Alvarez Sanz, M.C., Yracheta, J.M., Kunimoto, K., Li, Q., Levy, A.D., Rittenhouse, P.A. Pharmacol. Biochem. Behav. (1994)