Parkinsonism produced by tetrahydroisoquinoline (TIQ) or the analogues.
The effect of chronic administration of a probable endogenous dopaminergic neurotoxin, tetrahydroisoquinoline, has been examined on squirrel monkeys. Chronically administered TIQ produced motor symptoms similar to parkinsonism in squirrel monkeys even 7 days after discontinuation of TIQ and the symptoms were alleviated remarkably by L-DOPA treatment. Biochemical analysis of the brains of TIQ-treated monkeys revealed significant decrease in dopamine (DA) and total biopterin (BP) concentrations, and tyrosine hydroxylase ( TH) activity in the substantia nigra. Morphological changes of the substantia nigra of mice were also analyzed. The effect of long-term administration of N-methyl-TIQ, N-methyl-TIQ+, and N-methyl-norsalsolinol on aged monkeys was described.[1]References
- Parkinsonism produced by tetrahydroisoquinoline (TIQ) or the analogues. Yoshida, M., Ogawa, M., Suzuki, K., Nagatsu, T. Advances in neurology. (1993) [Pubmed]
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