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Chemical Compound Review

biopterin     2-amino-6-(1,2- dihydroxypropyl)-1H...

Synonyms: L-Biopterin, Pterin H B2, SureCN258468, AG-K-90904, SureCN4361085, ...
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High impact information on biopterin


Anatomical context of biopterin

  • Biochemical analysis of the brains of TIQ-treated monkeys revealed significant decrease in dopamine (DA) and total biopterin (BP) concentrations, and tyrosine hydroxylase (TH) activity in the substantia nigra [6].

Associations of biopterin with other chemical compounds

  • Full oxidation of 6BH(4) to 6 biopterin via H(2)O(2) can lead to a cytotoxic environment for epidermal melanocytes [7].
  • PH deficient patients excreted more B and Ne than healthy controls and again, newborns more than older children [8].
  • In PKU variants with deficiency of tetrahydrobiopterin (BH4), extreme pterin patterns were observed: in DHBS- and DHPR-deficient patients, less than 3.5 and more than 81% B were found, respectively [8].

Gene context of biopterin


Analytical, diagnostic and therapeutic context of biopterin


  1. Pteridines in the control of pigmentation. Schallreuter, K.U., Schulz-Douglas, V., Bünz, A., Beazley, W., Körner, C. J. Invest. Dermatol. (1997) [Pubmed]
  2. Tetrahydro-6-biopterin is associated with tetrahydro-7-biopterin in primary murine mast cells. Ziegler, I., Hültner, L. FEBS Lett. (1992) [Pubmed]
  3. Age determination in individual wild-caught Drosophila serrata using pteridine concentration. Robson, S.K., Vickers, M., Blows, M.W., Crozier, R.H. J. Exp. Biol. (2006) [Pubmed]
  4. A specific tetrahydrobiopterin binding domain on tyrosinase controls melanogenesis. Wood, J.M., Schallreuter-Wood, K.U., Lindsey, N.J., Callaghan, S., Gardner, M.L. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  5. Cytotoxicity of 6-biopterin to human melanocytes. Schallreuter, K.U., Büttner, G., Pittelkow, M.R., Wood, J.M., Swanson, N.N., Körner, C. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  6. Parkinsonism produced by tetrahydroisoquinoline (TIQ) or the analogues. Yoshida, M., Ogawa, M., Suzuki, K., Nagatsu, T. Advances in neurology. (1993) [Pubmed]
  7. Thioredoxin reductase - its role in epidermal redox status. Schallreuter, K.U., Wood, J.M. J. Photochem. Photobiol. B, Biol. (2001) [Pubmed]
  8. Excretion of pterins in phenylketonuria and phenylketonuria variants. Niederwieser, A., Curtius, H.C., Gitzelmann, R., Otten, A., Baerlocher, K., Blehovà, B., Berlow, S., Gröbe, H., Rey, F., Schaub, J., Scheibenreiter, S., Schmidt, H., Viscontini, M. Helvetica paediatrica acta. (1980) [Pubmed]
  9. Defective calcium transport in vitiliginous melanocytes. Schallreuter-Wood, K.U., Pittelkow, M.R., Swanson, N.N. Arch. Dermatol. Res. (1996) [Pubmed]
  10. Separation of pineal extracts by gelfiltration. VI. Isolation and identification from sheep pineals of biopterin; comparison of the isolated compound with some synthetic pteridines and the biological activity in in vitro and in vivo bioassays. van der Have-Kirchberg, M.L., de Morée, A., van Laar, J.F., Gerwig, G.J., Versluis, C., Ebels, I. J. Neural Transm. (1977) [Pubmed]
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