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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Genotoxicity of the phosphoramidate agent tabun (GA).

Five mutagenicity tests were performed on Agent GA (Tabun, phosphoramidocyanidic acid, dimethyl-, ethyl ester) as part of a program to demilitarize chemical warfare agents. GA was mutagenic in Salmonella spp. assays with S-9 and it was a direct-acting mutagen to mouse lymphoma cells. GA did not promote unscheduled DNA synthesis in rat hepatocytes; it induced sister chromatid exchanges in mouse cells in vitro but in vivo. The conclusion that GA is a weakly acting mutagen is supported by the fact that it was mutagenic in only three of the five assays, and that increases in mutagenicity were often less than 2-fold the controls and occurred near toxic levels.[1]

References

  1. Genotoxicity of the phosphoramidate agent tabun (GA). Wilson, B.W., Kawakami, T.G., Cone, N., Henderson, J.D., Rosenblatt, L.S., Goldman, M., Dacre, J.C. Toxicology (1994) [Pubmed]
 
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