The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Mutagenicity Tests

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mutagenicity Tests


High impact information on Mutagenicity Tests

  • Mutagenicity tests on water specimens form Gassim Region indicated the presence of possible carcinogens [6].
  • Temafloxacin, contrary to most other quinolones, was considered nonmutagenic in all mutagenicity tests conducted [7].
  • Marmoset CYP1A2 expressed in recombinant yeast activated 2-amino-3-methylimidazo [4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx) efficiently, and also activated 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP), but at a relatively lower rate in the umu mutagenicity test [8].
  • II is stable toward ligand exchange, reduction and disproportionation in the mutagenicity test medium and also in the presence of bacteria and the common cell reductant, glutathione [9].
  • The anti-neoplastic agent procarbazine is genetically active in a variety of short term mutagenicity tests, and it also possesses carcinogenic and teratogenic potential [10].

Chemical compound and disease context of Mutagenicity Tests


Biological context of Mutagenicity Tests


Anatomical context of Mutagenicity Tests


Associations of Mutagenicity Tests with chemical compounds


Gene context of Mutagenicity Tests


Analytical, diagnostic and therapeutic context of Mutagenicity Tests

  • The following bioassays were performed in urine samples: a) mutagenicity test and concentration of thioethers as markers of exposure, and b) excretion of D-glucaric acid and 6-beta-hydroxycortisol (related to 17-hydroxycorticosteroid excretion) as indicators of the inductive status of the microsomal enzyme system (phase-I) [35].
  • The antischistosomal agent, hycanthone methanesulfonate (HMS), was employed to illustrate the utility of carrying out several mutagenicity tests in a single concurrent animal experiment [36].
  • Therefore the presence of mutagenic impurities is not responsible for the carcinogenicity of commercial HC Blue No. 1. Discrepancies between the results of mutagenicity and carcinogenicity tests on hair dyes and other chemicals are discussed, and the value of short-term mutagenicity tests for assessing chemical safety is questioned [37].


  1. Presentation of benzo(a)pyrene to microsomal enzymes by asbestos fibers in the Salmonella/mammalian microsome mutagenicity test. Szyba, K., Lange, A. Environ. Health Perspect. (1983) [Pubmed]
  2. Evaluation of a genotoxicity test measuring DNA-strand breaks in mouse lymphoma cells by alkaline unwinding and hydroxyapatite elution. Garberg, P., Akerblom, E.L., Bolcsfoldi, G. Mutat. Res. (1988) [Pubmed]
  3. Evaluation of the mutagenicity and the tumor-promoting activity of parasite extracts: Schistosoma japonicum and Clonorchis sinensis. Ishii, A., Matsuoka, H., Aji, T., Hayatsu, H., Wataya, Y., Arimoto, S., Tokuda, H. Mutat. Res. (1989) [Pubmed]
  4. Mutagenic activities of simple nitrofuran derivatives. I. Comparison of related compounds in the phage inductest, chloroplast-bleaching and bacterial-repair and mutagenicity tests. Soska, J., Koukalová, B., Ebringer, L. Mutat. Res. (1981) [Pubmed]
  5. Comparison of the mutagenic potency of 2-chloroethanol, 2-bromoethanol, 1,2-epoxybutane, epichlorohydrin and glycidaldehyde in Klebsiella pneumoniae, Drosophila melanogaster and L5178Y mouse lymphoma cells. Knaap, A.G., Voogd, C.E., Kramers, P.G. Mutat. Res. (1982) [Pubmed]
  6. Water contamination and esophageal cancer at Gassim Region, Saudi Arabia. Amer, M.H., El-Yazigi, A., Hannan, M.A., Mohamed, M.E. Gastroenterology (1990) [Pubmed]
  7. Comparison of organ-specific toxicity of temafloxacin in animals and humans. Krasula, R.W., Pernet, A.G. Am. J. Med. (1991) [Pubmed]
  8. Marmoset CYP1A2: primary structure and constitutive expression in livers. Sakuma, T., Igarashi, T., Hieda, M., Ohgiya, S., Isogai, M., Ninomiya, S., Nagata, R., Nemoto, N., Kamataki, T. Carcinogenesis (1997) [Pubmed]
  9. In vitro DNA damage and mutations induced by a macrocyclic tetraamide chromium(V) complex: implications for the role of Cr(V) peptide complexes in chromium-induced cancers. Dillon, C.T., Lay, P.A., Bonin, A.M., Dixon, N.E., Collins, T.J., Kostka, K.L. Carcinogenesis (1993) [Pubmed]
  10. A demonstration of the in vitro bacterial mutagenicity of procarbazine, using the microtitre fluctuation test and large concentrations of S9 fraction. Gatehouse, D.G., Paes, D.J. Carcinogenesis (1983) [Pubmed]
  11. Bioactivation of cysteine conjugates of 1-nitropyrene oxides by cysteine conjugate beta-lyase purified from Peptostreptococcus magnus. Kataoka, K., Kinouchi, T., Akimoto, S., Ohnishi, Y. Appl. Environ. Microbiol. (1995) [Pubmed]
  12. Verapamil as a co-mutagen in the Salmonella/mammalian microsome mutagenicity test. Ferguson, L.R., Baguley, B.C. Mutat. Res. (1988) [Pubmed]
  13. Genotoxic activities of benzamidine and its N-hydroxylated metabolite benzamidoxime in Salmonella typhimurium and mammalian cells. Clement, B., Schmezer, P., Weber, H., Schlehofer, J.R., Schmitt, S., Pool, B.L. J. Cancer Res. Clin. Oncol. (1988) [Pubmed]
  14. Mutagenicity of several pancreatic carcinogenic derivatives of N-nitrosodipropylamine in the Ames assay. Wislocki, P., Gingell, R. Mutat. Res. (1980) [Pubmed]
  15. Dependence of the mutagenic power of heteroatomic dyes on their DNA-base-pair specificity. Mennigmann, H.D., Müller, W. Mutat. Res. (1981) [Pubmed]
  16. A practical procedure for testing DNA damage in vivo, proposed for a pre-screening of chemical carcinogens. Parodi, S., Taningher, M., Santi, L., Cavanna, M., Sciaba, L., Maura, A., Brambilla, G. Mutat. Res. (1978) [Pubmed]
  17. Genetic toxicity studies of 1,2,3,4-tetrahydro-9-acridinamine (tacrine). Zeiger, E., Erexson, G., Mortelmans, K., Thilagar, A. Mutat. Res. (1997) [Pubmed]
  18. Review of the toxicologic properties of medium-chain triglycerides. Traul, K.A., Driedger, A., Ingle, D.L., Nakhasi, D. Food Chem. Toxicol. (2000) [Pubmed]
  19. An evaluation of musk xylene in a battery of genotoxicity tests. Api, A.M., Ford, R.A., San, R.H. Food Chem. Toxicol. (1995) [Pubmed]
  20. Preclinical toxicology studies with acyclovir: genetic toxicity tests. Clive, D., Turner, N.T., Hozier, J., Batson, A.G., Tucker, W.E. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1983) [Pubmed]
  21. Mutagenic activity of three isomeric N-nitroso-N-methylaminopyridines towards Escherichia coli K-12 in in vitro and animal-mediated assays. Kerklaan, P., Bouter, S., Mohn, G. Carcinogenesis (1982) [Pubmed]
  22. A review of the genotoxicity of 1-ethyl-1-nitrosourea. Shibuya, T., Morimoto, K. Mutat. Res. (1993) [Pubmed]
  23. Sperm head abnormalities and dominant lethal effects of formaldehyde in albino rats. Odeigah, P.G. Mutat. Res. (1997) [Pubmed]
  24. Lack of evidence of omeprazole genotoxicity in Sprague-Dawley rats. Mereto, E., Ghia, M., Martelli, A., Brambilla, G. Mutagenesis (1993) [Pubmed]
  25. Fluoro-substituted N-nitrosamines. 1. Inactivity of N-nitrosobis(2,2,2-trifluoroethyl)amine in carcinogenicity and mutagenicity tests. Preussmann, R., Habs, M., Pool, B., Stummeyer, D., Lijinsky, W., Reuber, M.D. Carcinogenesis (1981) [Pubmed]
  26. Studies of the metabolic bioactivation of n-nitrosopyrrolidine in the rat. Cottrell, R.C., Blowers, S.D., Walters, D.G., Lake, B.G., Purchase, R., Phillips, J.C., Gangolli, S.D. Carcinogenesis (1983) [Pubmed]
  27. Results of in vitro and in vivo genetic toxicity tests on methyl isocyanate. Shelby, M.D., Allen, J.W., Caspary, W.J., Haworth, S., Ivett, J., Kligerman, A., Luke, C.A., Mason, J.M., Myhr, B., Tice, R.R. Environ. Health Perspect. (1987) [Pubmed]
  28. The potential of exposure biomarkers in epidemiologic studies of reproductive health. Hogue, C.J., Brewster, M.A. Environ. Health Perspect. (1991) [Pubmed]
  29. Fungal transformation of fluoranthene. Pothuluri, J.V., Freeman, J.P., Evans, F.E., Cerniglia, C.E. Appl. Environ. Microbiol. (1990) [Pubmed]
  30. Molecular cloning and functional analysis of cynomolgus monkey CYP1A2. Sakuma, T., Hieda, M., Igarashi, T., Ohgiya, S., Nagata, R., Nemoto, N., Kamataki, T. Biochem. Pharmacol. (1998) [Pubmed]
  31. Expression of recombinant human cytochrome P450 1A2 in Escherichia coli bacterial mutagenicity tester strain. Chun, Y.J. Arch. Pharm. Res. (1998) [Pubmed]
  32. An evaluation of genotoxicity tests with Musk ketone. Api, A.M., Pfitzer, E.A., San, R.H. Food Chem. Toxicol. (1996) [Pubmed]
  33. Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood. Baum, M., Fauth, E., Fritzen, S., Herrmann, A., Mertes, P., Merz, K., Rudolphi, M., Zankl, H., Eisenbrand, G. Mutat. Res. (2005) [Pubmed]
  34. Histocompatibility gene mutation rates, spontaneous and induced by the chemical mutagen procarbazine. Harnasch, D., Stumpf, R. Mutat. Res. (1982) [Pubmed]
  35. Biological monitoring of genotoxic hazard in workers of the rubber industry. Moretti, M., Villarini, M., Scassellati-Sforzolini, G., Monarca, S., Libraro, M., Fatigoni, C., Donato, F., Leonardis, C., Perego, L. Environ. Health Perspect. (1996) [Pubmed]
  36. A combined testing protocol approach for mutagenicity testing. Connor, T.H., Meyne, J., Molina, L., Legator, M.S. Mutat. Res. (1979) [Pubmed]
  37. Failure of short-term in vitro mutagenicity tests to predict the animal carcinogenicity of hair dyes. Burnett, C.M., Corbett, J.F. Food Chem. Toxicol. (1987) [Pubmed]
WikiGenes - Universities