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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pupillary changes after intracisternal injection of papaverine.

Pupillary changes attributed to intracisternal papaverine injection were observed in three patients who underwent pterional craniotomy and clipping of a supratentorial aneurysm in which the oculomotor nerve was not manipulated. A fixed and dilated pupil on the side of the craniotomy lasted 2 to 4 hours after intracisternal papaverine instillation. These observations suggest that a dilated, nonreactive pupil subsequent to an uncomplicated pterional craniotomy for aneurysm, in which oculomotor nerve trauma has not occurred, may not be an ominous finding but may represent a transient phenomenon related to intracisternal papaverine injection.[1]


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