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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Oculomotor Nerve

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Disease relevance of Oculomotor Nerve

  • 1. The effects of tetanic stimulation of the oculomotor nerve on transmission through the avian ciliary ganglion have been determined by use of the amplitude of the compound action potential recorded in the ciliary nerve, in the presence of hexamethonium (300 microM), as a measure of synaptic efficacy [1].
  • The authors present a proved case of neurilemmoma arising from the oculomotor nerve in which MR imaging, including enhancement by gadopentetate dimeglumine, dynamic study and three-dimensional gradient echo images, provided much more precise definition of the tumor [2].
  • This 6-year-old boy, after recovery from prolonged coma following head trauma, exhibited the rare phenomenon of bilateral oculomotor nerve misdirection manifested by ipsilateral eyelid elevation on adduction of either eye [3].
  • PURPOSE: To discuss the sensitivity of three-dimensional time-of-flight (3D TOF) magnetic resonance angiography (MRA) for detecting aneurysms causing third cranial nerve palsy and to propose guidelines for the use of MRA in the evaluation of patients with different clinical presentations of oculomotor nerve palsy [4].
  • Miosis from echothiophate in patients with total oculomotor nerve paralysis from intracranial abnormalities [5].

High impact information on Oculomotor Nerve

  • Transient oculomotor nerve palsy. Association with thiazide-induced glucose intolerance [6].
  • We hypothesize that CFEOM2 results from an analogous developmental defect to CFEOM1, one that affects both the superior and inferior divisions of the oculomotor nerve and their corresponding alpha motoneurons and extraocular muscles [7].
  • Subjects with the R954W and R954Q substitutions frequently exhibited A-pattern strabismus, with misinnervation of the lateral rectus muscle by an oculomotor nerve branch [8].
  • The authors have previously demonstrated that CFEOM1 results from a developmental absence of the superior division of the oculomotor nerve [9].
  • A large GnRH-immunoreactive (ir) nucleus extends rostrocaudally for approximately 1.5 mm along and adjacent to the midline of the midbrain near the area of the oculomotor nerve [10].

Chemical compound and disease context of Oculomotor Nerve


Biological context of Oculomotor Nerve

  • A branch of the oculomotor nerve innervates heater organs, and, in this paper, we demonstrate that heater cells contain large 'endplate-like' clusters of acetylcholine receptors that appear to provide a mechanism for nervous control of thermogenesis [14].

Anatomical context of Oculomotor Nerve

  • At the distal site of this ring, TH-positive fibers were lost or markedly reduced in number in the abducent and trochlear nerves and were distributed mostly in the ophthalmic and oculomotor nerves [15].
  • The present study suggests that improvement of intraneural microcirculation by PGE1 administration results in an immediate recovery from diabetic oculomotor nerve palsy [16].
  • We measured and analyzed unmyelinated nerve fibers in the human oculomotor nerve with an image analyzer and a computer, using a new staining method, the Luxol fast blue-periodic acid-Schiff-hematoxylin (LPH) discriminative staining method which is the only one suitable for morphometric research on nervous tissues [17].

Associations of Oculomotor Nerve with chemical compounds


Gene context of Oculomotor Nerve


Analytical, diagnostic and therapeutic context of Oculomotor Nerve

  • These observations suggest that a dilated, nonreactive pupil subsequent to an uncomplicated pterional craniotomy for aneurysm, in which oculomotor nerve trauma has not occurred, may not be an ominous finding but may represent a transient phenomenon related to intracisternal papaverine injection [12].


  1. The effect of ions and second messengers on long-term potentiation of chemical transmission in avian ciliary ganglia. Scott, T.R., Bennett, M.R. Br. J. Pharmacol. (1993) [Pubmed]
  2. MR imaging of oculomotor nerve neurilemmoma. Kadota, T., Miyawaki, Y., Nakagawa, H., Ishiguro, S., Kuroda, C. Magnetic resonance imaging. (1993) [Pubmed]
  3. Bilateral aberrant regeneration of the third cranial nerve following trauma. Case report. Keane, J.R. J. Neurosurg. (1975) [Pubmed]
  4. The emerging role of magnetic resonance angiography in the management of patients with third cranial nerve palsy. Jacobson, D.M., Trobe, J.D. Am. J. Ophthalmol. (1999) [Pubmed]
  5. Miosis from echothiophate in patients with total oculomotor nerve paralysis from intracranial abnormalities. Mindel, J.S. Am. J. Ophthalmol. (1981) [Pubmed]
  6. Transient oculomotor nerve palsy. Association with thiazide-induced glucose intolerance. Miller, N.R., Moses, H. JAMA (1978) [Pubmed]
  7. Congenital fibrosis of the extraocular muscles type 2, an inherited exotropic strabismus fixus, maps to distal 11q13. Wang, S.M., Zwaan, J., Mullaney, P.B., Jabak, M.H., Al-Awad, A., Beggs, A.H., Engle, E.C. Am. J. Hum. Genet. (1998) [Pubmed]
  8. Magnetic resonance imaging evidence for widespread orbital dysinnervation in congenital fibrosis of extraocular muscles due to mutations in KIF21A. Demer, J.L., Clark, R.A., Engle, E.C. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  9. CFEOM3: a new extraocular congenital fibrosis syndrome that maps to 16q24.2-q24.3. Doherty, E.J., Macy, M.E., Wang, S.M., Dykeman, C.P., Melanson, M.T., Engle, E.C. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  10. Gonadotropin hormone-releasing hormone (GnRH) immunoreactivity in the mesencephalon of sharks and rays. Wright, D.E., Demski, L.S. J. Comp. Neurol. (1991) [Pubmed]
  11. Cranial nerves of the coelacanth, Latimeria chalumnae [Osteichthyes: Sarcopterygii: Actinistia], and comparisons with other craniata. Northcutt, R.G., Bemis, W.E. Brain Behav. Evol. (1993) [Pubmed]
  12. Pupillary changes after intracisternal injection of papaverine. Pritz, M.B. Surgical neurology. (1994) [Pubmed]
  13. Congenital toxoplasmosis associated with acquired oculomotor nerve (CN III) palsy. Perry, D.D., Marritt, J.C., Greenwood, R.S., Collier, A.M., Tennison, M.B. Journal of pediatric ophthalmology and strabismus. (1982) [Pubmed]
  14. Characterization of ryanodine receptor and Ca2+-ATPase isoforms in the thermogenic heater organ of blue marlin (Makaira nigricans). Morrissette, J.M., Franck, J.P., Block, B.A. J. Exp. Biol. (2003) [Pubmed]
  15. Immunohistochemical determination of the sympathetic pathway in the orbit via the cranial nerves in humans. Oikawa, S., Kawagishi, K., Yokouchi, K., Fukushima, N., Moriizumi, T. J. Neurosurg. (2004) [Pubmed]
  16. Immediate improvement of diabetic mononeuropathy after intravenous administration of prostaglandin E1. Shimizu, H., Shimomura, Y., Inukai, T., Takahashi, M., Uehara, Y., Kobayashi, I., Kobayashi, S. Jpn. J. Med. (1990) [Pubmed]
  17. Unmyelinated nerve fiber analysis of the human oculomotor nerve. Kawamura, N., Matsumoto, K., Wada, A., Goto, N. Okajimas folia anatomica Japonica. (2000) [Pubmed]
  18. Effects of hexamethonium, biperiden and phentolamine on the vasoconstrictive effects of oculomotor nerve stimulation in rabbits. Bill, A., Stjernschantz, J., Alm, A. Exp. Eye Res. (1976) [Pubmed]
  19. Somatotopic organization of primary afferent perikarya of the guinea-pig extraocular muscles in the trigeminal ganglion: a post-mortem DiI-tracing study. Aigner, M., Robert Lukas, J., Denk, M., Ziya-Ghazvini, F., Kaider, A., Mayr, R. Exp. Eye Res. (2000) [Pubmed]
  20. Effects of intracranial oculomotor nerve stimulation on ocular blood flow in rabbits: modification by indomethacin. Stjernschantz, J., Alm, A., Bill, A. Exp. Eye Res. (1976) [Pubmed]
  21. Oculomotor nerve invasion of acute myelogenous leukemia demonstrated by magnetic resonance imaging. Tabata, M., Yoshida, M., Takahashi, H., Toshima, M., Takatoku, M., Tsunoda, J., Kikuno, M., Hatake, K., Miura, Y. Leuk. Lymphoma (1998) [Pubmed]
  22. The influence of L-acetylcarnitine on reinnervation of the oculomotor nerve. Pettorossi, V.E., Draicchio, F., Fernandez, E., Pallini, R. International journal of clinical pharmacology research. (1993) [Pubmed]
  23. Distribution of neurons expressing calcitonin gene-related peptide mRNAs in the brain stem, spinal cord and dorsal root ganglia of rat and guinea-pig. Réthelyi, M., Metz, C.B., Lund, P.K. Neuroscience (1989) [Pubmed]
  24. Multiple sclerosis presenting as isolated oculomotor nerve palsy. Uitti, R.J., Rajput, A.H. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1986) [Pubmed]
  25. Hemimegalencephaly and intractable epilepsy: complications of hemispherectomy and their correlations with the surgical technique. A report on 15 cases. Di Rocco, C., Iannelli, A. Pediatric neurosurgery. (2000) [Pubmed]
  26. Isolated oculomotor nerve palsy with pupillary abnormality in systemic lupus erythematosus. Lee, J.S., Roh, Y.B., Oum, B.S., Kwak, I.S. Journal of pediatric ophthalmology and strabismus. (2000) [Pubmed]
  27. A study on the sectional anatomy of the oculomotor nerve and its related blood vessels with plastination and MRI. Zhang, W.G., Zhang, S.X., Wu, B.H. Surgical and radiologic anatomy : SRA. (2002) [Pubmed]
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