Disease relevance of Oculomotor Nerve

• 1. The effects of tetanic stimulation of the oculomotor nerve on transmission through the avian ciliary ganglion have been determined by use of the amplitude of the compound action potential recorded in the ciliary nerve, in the presence of hexamethonium (300 microM), as a measure of synaptic efficacy [1].
• The authors present a proved case of neurilemmoma arising from the oculomotor nerve in which MR imaging, including enhancement by gadopentetate dimeglumine, dynamic study and three-dimensional gradient echo images, provided much more precise definition of the tumor [2].
• This 6-year-old boy, after recovery from prolonged coma following head trauma, exhibited the rare phenomenon of bilateral oculomotor nerve misdirection manifested by ipsilateral eyelid elevation on adduction of either eye [3].
• PURPOSE: To discuss the sensitivity of three-dimensional time-of-flight (3D TOF) magnetic resonance angiography (MRA) for detecting aneurysms causing third cranial nerve palsy and to propose guidelines for the use of MRA in the evaluation of patients with different clinical presentations of oculomotor nerve palsy [4].
• Miosis from echothiophate in patients with total oculomotor nerve paralysis from intracranial abnormalities [5].

High impact information on Oculomotor Nerve

• Transient oculomotor nerve palsy. Association with thiazide-induced glucose intolerance [6].
• We hypothesize that CFEOM2 results from an analogous developmental defect to CFEOM1, one that affects both the superior and inferior divisions of the oculomotor nerve and their corresponding alpha motoneurons and extraocular muscles [7].
• Subjects with the R954W and R954Q substitutions frequently exhibited A-pattern strabismus, with misinnervation of the lateral rectus muscle by an oculomotor nerve branch [8].
• The authors have previously demonstrated that CFEOM1 results from a developmental absence of the superior division of the oculomotor nerve [9].
• A large GnRH-immunoreactive (ir) nucleus extends rostrocaudally for approximately 1.5 mm along and adjacent to the midline of the midbrain near the area of the oculomotor nerve [10].

Chemical compound and disease context of Oculomotor Nerve

• As in gnathostomes generally, Latimeria has a ciliary ganglion but its cells are located intracranially in the root of the oculomotor nerve, and their processes reach the eye via oculomotor and profundal rami [11].
• Pupillary changes attributed to intracisternal papaverine injection were observed in three patients who underwent pterional craniotomy and clipping of a supratentorial aneurysm in which the oculomotor nerve was not manipulated [12].
• Congenital toxoplasmosis associated with acquired oculomotor nerve (CN III) palsy [13].

Biological context of Oculomotor Nerve

• A branch of the oculomotor nerve innervates heater organs, and, in this paper, we demonstrate that heater cells contain large 'endplate-like' clusters of acetylcholine receptors that appear to provide a mechanism for nervous control of thermogenesis [14].

Anatomical context of Oculomotor Nerve

• At the distal site of this ring, TH-positive fibers were lost or markedly reduced in number in the abducent and trochlear nerves and were distributed mostly in the ophthalmic and oculomotor nerves [15].
• The present study suggests that improvement of intraneural microcirculation by PGE1 administration results in an immediate recovery from diabetic oculomotor nerve palsy [16].
• We measured and analyzed unmyelinated nerve fibers in the human oculomotor nerve with an image analyzer and a computer, using a new staining method, the Luxol fast blue-periodic acid-Schiff-hematoxylin (LPH) discriminative staining method which is the only one suitable for morphometric research on nervous tissues [17].

Associations of Oculomotor Nerve with chemical compounds

• Effects of hexamethonium, biperiden and phentolamine on the vasoconstrictive effects of oculomotor nerve stimulation in rabbits [18].
• The primary afferent perikarya were labeled by post-mortem application of the carbocyanine DiI on the oculomotor nerve branches near their entrance into the single EOMs [19].
• Effects of intracranial oculomotor nerve stimulation on ocular blood flow in rabbits: modification by indomethacin [20].
• Intrathecal injections of methotrexate and cytosine arabinoside were partially effective and repeated MRI showed shrinkage of the enlarged oculomotor nerves, after therapy [21].
• The influence of L-acetylcarnitine on reinnervation of the oculomotor nerve [22].

Gene context of Oculomotor Nerve

• In the guinea-pig, in contrast, calcitonin gene-related peptide mRNA was localized also to motoneurons of the abducens, trigeminal, trochlear and oculomotor nerves [23].
• Multiple sclerosis presenting as isolated oculomotor nerve palsy [24].
• Temporary complications, which resolved spontaneously or following medical therapy, included fever, wound breakdown, worsening of preoperative motor deficit, unilateral third cranial nerve deficit, dystonia, and anemia [25].
• Isolated oculomotor nerve palsy with pupillary abnormality in systemic lupus erythematosus [26].
• To obtain normal images and sectional anatomical data of the oculomotor nerve and its related arteries, the optimal angles and the length of intracisternal segment of the oculomotor nerve were measured on MPR images [27].

Analytical, diagnostic and therapeutic context of Oculomotor Nerve

• These observations suggest that a dilated, nonreactive pupil subsequent to an uncomplicated pterional craniotomy for aneurysm, in which oculomotor nerve trauma has not occurred, may not be an ominous finding but may represent a transient phenomenon related to intracisternal papaverine injection [12].

References