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MeSH Review


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Disease relevance of Aneurysm


High impact information on Aneurysm


Chemical compound and disease context of Aneurysm

  • These data suggest an important role for leukocyte-derived OPN in mediating Ang II-accelerated atherosclerosis and aneurysm formation [6].
  • Radionuclide and hemodynamic assessment of left ventricular functional reserve in patients with left ventricular aneurysm and congestive cardiac failure. Response to exercise stress and isosorbide dinitrate [11].
  • Technetium 99m stannous pyrophosphate myocardial imaging in patients with and without left ventricular aneurysm [12].
  • We demonstrate that spinal cord compression (5 s with a 50 g aneurysm clip) at T6 in rats results in oxidative stress that is extensive (significant increases in oxidative stress seen at C3 and L4) and rapid in onset [13].
  • The posterior vitreous concentration of fluorescein was significantly increased in diabetic subjects with one or no aneurysms as compared with normals [14].

Biological context of Aneurysm


Anatomical context of Aneurysm


Gene context of Aneurysm

  • Mutation detection of PKD1 identifies a novel mutation common to three families with aneurysms and/or very-early-onset disease [25].
  • The pathogenesis of aneurysm formation was studied in Blotchy (Blo) mice which have a hereditary defect in collagen and elastin cross-linking [26].
  • The results indicated that mutations in the gene for type III procollagen (COL3A1) are not a common cause of either intracranial artery aneurysms or cervical artery dissections [27].
  • In mouse models of atherosclerosis, urokinase-mediated plasmin generation plays a role in activation of several macrophage-derived MMPs (MMP-3, -9, -12 and -13), triggering elastolysis and collagenolysis, resulting in media destruction and aneurysm formation [28].
  • CONCLUSIONS: The presence of activated MMP9 and MMP2 might contribute to the degradation of the extracellular matrix proteins that occurs during the development of aneurysms [29].

Analytical, diagnostic and therapeutic context of Aneurysm


  1. Images in clinical medicine. Renal aneurysms in hepatitis B-associated polyarteritis nodosa. Chauveau, D., Christophe, J.L. N. Engl. J. Med. (1995) [Pubmed]
  2. Recent insights into coronary collateral circulation. Sasayama, S., Fujita, M. Circulation (1992) [Pubmed]
  3. C-reactive protein as a predictor of infarct expansion and cardiac rupture after a first Q-wave acute myocardial infarction. Anzai, T., Yoshikawa, T., Shiraki, H., Asakura, Y., Akaishi, M., Mitamura, H., Ogawa, S. Circulation (1997) [Pubmed]
  4. Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus. Fontaine, V., Touat, Z., Mtairag, e.l. .M., Vranckx, R., Louedec, L., Houard, X., Andreassian, B., Sebbag, U., Palombi, T., Jacob, M.P., Meilhac, O., Michel, J.B. Am. J. Pathol. (2004) [Pubmed]
  5. Early changes of experimentally induced cerebral aneurysms in rats. Light-microscopic study. Hazama, F., Kataoka, H., Yamada, E., Kayembe, K., Hashimoto, N., Kojima, M., Kim, C. Am. J. Pathol. (1986) [Pubmed]
  6. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. Bruemmer, D., Collins, A.R., Noh, G., Wang, W., Territo, M., Arias-Magallona, S., Fishbein, M.C., Blaschke, F., Kintscher, U., Graf, K., Law, R.E., Hsueh, W.A. J. Clin. Invest. (2003) [Pubmed]
  7. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. Daugherty, A., Manning, M.W., Cassis, L.A. J. Clin. Invest. (2000) [Pubmed]
  8. Reduced transplant arteriosclerosis in plasminogen-deficient mice. Moons, L., Shi, C., Ploplis, V., Plow, E., Haber, E., Collen, D., Carmeliet, P. J. Clin. Invest. (1998) [Pubmed]
  9. Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model. Allaire, E., Forough, R., Clowes, M., Starcher, B., Clowes, A.W. J. Clin. Invest. (1998) [Pubmed]
  10. Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart. Saito, Y., Nakao, K., Arai, H., Nishimura, K., Okumura, K., Obata, K., Takemura, G., Fujiwara, H., Sugawara, A., Yamada, T. J. Clin. Invest. (1989) [Pubmed]
  11. Radionuclide and hemodynamic assessment of left ventricular functional reserve in patients with left ventricular aneurysm and congestive cardiac failure. Response to exercise stress and isosorbide dinitrate. Stephens, J.D., Dymond, D.S., Spurrell, R.A. Circulation (1980) [Pubmed]
  12. Technetium 99m stannous pyrophosphate myocardial imaging in patients with and without left ventricular aneurysm. Ahmad, M., Dubiel, J.P., Verdon, T.A., Martin, R.H. Circulation (1976) [Pubmed]
  13. Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function. Kamencic, H., Griebel, R.W., Lyon, A.W., Paterson, P.G., Juurlink, B.H. FASEB J. (2001) [Pubmed]
  14. Characterization of the early stages of diabetic retinopathy by vitreous fluorophotometry. Cunha-Vaz, J.G., Gray, J.R., Zeimer, R.C., Mota, M.C., Ishimoto, B.M., Leite, E. Diabetes (1985) [Pubmed]
  15. Experimental Trypanosoma cruzi cardiomyopathy in BALB/c mice. The potential role of intravascular platelet aggregation in its genesis. Rossi, M.A., Gonçalves, S., Ribeiro-dos-Santos, R. Am. J. Pathol. (1984) [Pubmed]
  16. Sympathetic nervous system activity in patients with subarachnoid hemorrhage. Benedict, C.R., Loach, A.B. Stroke (1978) [Pubmed]
  17. Left ventricular cavity-to-myocardial count ratio: a new parameter for detecting resting left ventricular dysfunction directly from tomographic thallium perfusion scintigraphy. Roberti, R.R., Van Tosh, A., Baruchin, M.A., Gallagher, R., Friedman, P., Ventura, B., Horowitz, S.F. J. Nucl. Med. (1993) [Pubmed]
  18. Matrix metalloproteinases: a therapeutic target in cardiovascular disease. Sierevogel, M.J., Pasterkamp, G., de Kleijn, D.P., Strauss, B.H. Curr. Pharm. Des. (2003) [Pubmed]
  19. Increased matrix metalloproteinase 2 expression in vascular smooth muscle cells cultured from abdominal aortic aneurysms. Crowther, M., Goodall, S., Jones, J.L., Bell, P.R., Thompson, M.M. J. Vasc. Surg. (2000) [Pubmed]
  20. Angiotensin II increases urokinase-type plasminogen activator expression and induces aneurysm in the abdominal aorta of apolipoprotein E-deficient mice. Wang, Y.X., Martin-McNulty, B., Freay, A.D., Sukovich, D.A., Halks-Miller, M., Li, W.W., Vergona, R., Sullivan, M.E., Morser, J., Dole, W.P., Deng, G.G. Am. J. Pathol. (2001) [Pubmed]
  21. Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms. López-Candales, A., Holmes, D.R., Liao, S., Scott, M.J., Wickline, S.A., Thompson, R.W. Am. J. Pathol. (1997) [Pubmed]
  22. Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms ("dilated coronopathy"). Krüger, D., Stierle, U., Herrmann, G., Simon, R., Sheikhzadeh, A. J. Am. Coll. Cardiol. (1999) [Pubmed]
  23. Mesenteric vascular problems. A 26-year experience. Rogers, D.M., Thompson, J.E., Garrett, W.V., Talkington, C.M., Patman, R.D. Ann. Surg. (1982) [Pubmed]
  24. Syphilitic aortic aneurysm presenting with the superior vena cava syndrome. Phillips, P.L., Amberson, J.B., Libby, D.M. Am. J. Med. (1981) [Pubmed]
  25. Mutation detection of PKD1 identifies a novel mutation common to three families with aneurysms and/or very-early-onset disease. Watnick, T., Phakdeekitcharoen, B., Johnson, A., Gandolph, M., Wang, M., Briefel, G., Klinger, K.W., Kimberling, W., Gabow, P., Germino, G.G. Am. J. Hum. Genet. (1999) [Pubmed]
  26. Spontaneous aortic aneurysms in blotchy mice. Andrews, E.J., White, W.J., Bullock, L.P. Am. J. Pathol. (1975) [Pubmed]
  27. Exclusion of mutations in the gene for type III collagen (COL3A1) as a common cause of intracranial aneurysms or cervical artery dissections: results from sequence analysis of the coding sequences of type III collagen from 55 unrelated patients. Kuivaniemi, H., Prockop, D.J., Wu, Y., Madhatheri, S.L., Kleinert, C., Earley, J.J., Jokinen, A., Stolle, C., Majamaa, K., Myllylä, V.V. Neurology (1993) [Pubmed]
  28. Plasmin and matrix metalloproteinases in vascular remodeling. Lijnen, H.R. Thromb. Haemost. (2001) [Pubmed]
  29. Activated forms of MMP2 and MMP9 in abdominal aortic aneurysms. Sakalihasan, N., Delvenne, P., Nusgens, B.V., Limet, R., Lapière, C.M. J. Vasc. Surg. (1996) [Pubmed]
  30. Alpha 1-antitrypsin deficiency in intracranial aneurysms and cervical artery dissection. Schievink, W.I., Prakash, U.B., Piepgras, D.G., Mokri, B. Lancet (1994) [Pubmed]
  31. Risk factors for aneurysm rupture in patients kept under ultrasound surveillance. UK Small Aneurysm Trial Participants. Brown, L.C., Powell, J.T. Ann. Surg. (1999) [Pubmed]
  32. Myocardial stunning in hypertrophic cardiomyopathy: recovery predicted by single photon emission computed tomographic thallium-201 scintigraphy. Fine, D.G., Clements, I.P., Callahan, M.J. J. Am. Coll. Cardiol. (1989) [Pubmed]
  33. Ventricular septal defect associated with aneurysm of the membranous septum. Beerman, L.B., Park, S.C., Fischer, D.R., Fricker, F.J., Mathews, R.A., Neches, W.H., Lenox, C.C., Zuberbuhler, J.R. J. Am. Coll. Cardiol. (1985) [Pubmed]
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