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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Concentrations of cefodizime in bronchial secretions after single intravenous administration.

The concentrations of cefodizime (HR 221, CAS 69739-16-8) in bronchial secretions were measured after administration of a single intravenous bolus of 2 g in 19 patients requiring fibreoptic bronchoscopy for diagnostic purposes or as therapeutic follow-up. These concentrations, which were obtained in absence of inflammation of the mucosa, were compared to serum concentrations obtained simultaneously. The penetration into bronchial secretions was rapid, maximum levels of between 1 and 5 mg/kg being already observed 1 h after injection. Most concentrations remained about 1 mg/kg throughout the whole observation period of about 5.5 h. The percent penetration amounted to about 1.5% of the corresponding serum concentrations. Conclusion: Concentrations well above the MIC90s of the relevant respiratory pathogens--S. pneumoniae, M. catarrhalis, H. influenzae, K. pneumoniae--and Enterobacteriaceae were reached in bronchial secretions after intravenous injection of a single 2 g dose of cefodizime. Even higher levels may be expected in the usual condition of inflamed bronchial mucosa as found in respiratory infections.[1]


  1. Concentrations of cefodizime in bronchial secretions after single intravenous administration. Pacheco, Y., Pirollet, B., Taviot, B., Coppere, B., Perrin-Fayolle, M., Dagrosa, E.E., Damm, D. Arzneimittel-Forschung. (1993) [Pubmed]
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