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Chemical Compound Review

THR-221     (6R,7R)-7-[[(2Z)-2-(2-amino- 1,3-thiazol-4...

Synonyms:
 
 
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Disease relevance of THR-221

 

High impact information on THR-221

 

Chemical compound and disease context of THR-221

  • When tested against the E. coli Ec-89 infection induced in the rat uterus, the activity of HR 221 given to rats once daily was equal to that of CTX or CMZ given at the same dose twice daily [4].
 

Biological context of THR-221

  • THR-221 caused no increases in the number of chromosomal aberrants at dose levels of 0.75, 1.5, 3.0 and 6.0 mg/ml in the absence and presence of the metabolic activation [8].

References

  1. Ceftazidime, ceftizoxime, cefotaxime and HR 221 in experimental chronic Escherichia coli pyelonephritis in rats. Marre, R., Herhahn, D., Schulz, E., Freiesleben, H., Sack, K. Infection (1983) [Pubmed]
  2. Pharmacokinetics of cefodizime in normal individuals and in patients with renal failure. el Guinaidy, M.A., Nawishy, S., Abd el Bary, M., Sabbour, M.S. Chemotherapy. (1991) [Pubmed]
  3. In vitro antibacterial activity and beta-lactamase stability of cefodizime, a new cephalosporin antibiotic. Kasai, K., Tsuji, A., Miyazaki, S., Goto, S., Fujimoto, K., Masuyoshi, S., Arai, S. The Japanese journal of antibiotics. (1984) [Pubmed]
  4. In vivo antibacterial activity of cefodizime, a new cephalosporin antibiotic. Kasai, K., Tsuji, A., Miyazaki, S., Goto, S., Fujimoto, K., Masuyoshi, S., Arai, S. The Japanese journal of antibiotics. (1984) [Pubmed]
  5. Cefodizime in acute purulent exacerbations of chronic respiratory disease. Maesen, F.P., Davies, B.I., Baur, C., Sumajow, C.A. J. Antimicrob. Chemother. (1988) [Pubmed]
  6. Cefodizime (HR 221) potentiation of human neutrophil oxygen-independent bactericidal activity. Labro, M.T., Amit, N., Babin-Chevaye, C., Hakim, J. J. Antimicrob. Chemother. (1987) [Pubmed]
  7. Concentrations of cefodizime in bronchial secretions after single intravenous administration. Pacheco, Y., Pirollet, B., Taviot, B., Coppere, B., Perrin-Fayolle, M., Dagrosa, E.E., Damm, D. Arzneimittel-Forschung. (1993) [Pubmed]
  8. Mutagenicity test of cefodizime sodium. Ohuchida, A., Yoshida, R. The Journal of toxicological sciences. (1988) [Pubmed]
 
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