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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The influence of L-acetylcarnitine on reinnervation of the oculomotor nerve.

In guinea-pigs the oral administration of L-acetylcarnitine (L-AC) markedly favours the process of reinnervation of the oculomotor nerve sectioned at intracranial level. The gains of the horizontal and vertical vestibulo-ocular reflexes (HVOR, VVOR) were taken into consideration in testing the functional recovery of the nerve. As a consequence of the drug administration, 24 weeks after the operation the gains of the treated animals were higher than those of the controls. Reduction of misalignments of the stimulus-response orientation was also observed in treated animals as compared to the controls. This suggests that L-AC potentiates motor reinnervation by enhancing the nerve-growing processes and favouring a better consolidation of the appropriate neuromuscular synapses. The increased gain, and the improvement of the alignment in ocular responses, due to L-AC would allow for an increase of visual function during head movement by optimizing gaze stability.[1]


  1. The influence of L-acetylcarnitine on reinnervation of the oculomotor nerve. Pettorossi, V.E., Draicchio, F., Fernandez, E., Pallini, R. International journal of clinical pharmacology research. (1993) [Pubmed]
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