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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Haptoglobin polymorphism and the immune response after hepatitis B vaccination.

One hundred healthy Caucasian medical students (age 22 +/- 1 years) were vaccinated with a recombinant hepatitis B vaccine and their haptoglobin types were determined. A relationship between haptoglobin type and immune response to the vaccine was observed. Subjects with a 2-2 haptoglobin phenotype produced significantly lower hepatitis B antibody titres than those having a 1-1 or 2-1 haptoglobin phenotype. The haptoglobin phenotypes not only influenced the magnitude but also the kinetics of the anti-HBs response. For all haptoglobin types, haptoglobin concentration and immune response to the vaccine behaved independently.[1]

References

  1. Haptoglobin polymorphism and the immune response after hepatitis B vaccination. Louagie, H., Delanghe, J., Desombere, I., De Buyzere, M., Hauser, P., Leroux-Roels, G. Vaccine (1993) [Pubmed]
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