Antiepileptogenic action of 7-chlorokynurenic acid on amygdala kindling of rats.
To investigate the role of strychnine-insensitive glycine receptors in epilepsy, we studied the effects of 7-chlorokynurenic acid (7-CK), a selective strychnine-insensitive glycine receptor antagonist, on amygdala kindling development and previously amygdala-kindled seizures in rats. ICV administration of 7-CK (10 or 20 micrograms) suppressed amygdala kindling development, according to the motor seizure stage and afterdischarge development, in a dose-dependent manner. However, 7-CK had no significant effect on previously kindled seizures at either of these doses nor did 20 micrograms at any time (15 min, 30 min, 2 h, and 24 h) after injection studied. These results demonstrate that this selective strychnine-insensitive glycine receptor antagonist has antiepileptogenic activity and suggest a role for the glycine receptors in the contribution of the NMDA receptor complex to epileptogenic events.[1]References
- Antiepileptogenic action of 7-chlorokynurenic acid on amygdala kindling of rats. Namba, T., Morimoto, K., Yamada, N., Otsuki, S. Pharmacol. Biochem. Behav. (1993) [Pubmed]
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