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Chemical Compound Review

Lopac-C-121     7-chloro-4-oxo-1H-quinoline- 2-carboxylic acid

Synonyms: Tocris-0237, CHEMBL311389, SureCN157187, AG-A-91643, SureCN2680493, ...
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Disease relevance of Lopac-C-121


Psychiatry related information on Lopac-C-121


High impact information on Lopac-C-121


Chemical compound and disease context of Lopac-C-121


Biological context of Lopac-C-121


Anatomical context of Lopac-C-121


Associations of Lopac-C-121 with other chemical compounds


Gene context of Lopac-C-121


Analytical, diagnostic and therapeutic context of Lopac-C-121

  • Rat behaviors in the elevated T-maze (ETM) were evaluated following tectum microinjections of either glycine (GLY, 1, 10, 80 and 120 nmol) or d-serine (D-SER, 160 and 320 nmol), the putative endogenous agonists of GLY-B site at NMDA receptor, or the respective antagonist 7-chloro-kynurenic acid (7CK, 8 nmol) [26].
  • Further perfusion together to high (+ 2 mM) calcium with 0.5 mM penicillin or with 50 microM CGS 19755, but not with 50 microM 7-chlorokynurenic acid significantly decreases the degree of paired-pulse inhibition as revealed by a significative increase in the R2/R1 ratio [27].


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  18. Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents. Battaglia, G., La Russa, M., Bruno, V., Arenare, L., Ippolito, R., Copani, A., Bonina, F., Nicoletti, F. Brain Res. (2000) [Pubmed]
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  20. Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. Martin, G., Guadaño-Ferraz, A., Morte, B., Ahmed, S., Koob, G.F., De Lecea, L., Siggins, G.R. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
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  23. Beta-endorphin C-terminal peptide evokes arachidonic acid release from cortical neurones. Haynes, L. Eur. J. Pharmacol. (1991) [Pubmed]
  24. WAY 100635, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal administration of scopolamine or 7-chloro-kynurenic acid. Carli, M., Bonalumi, P., Samanin, R. Brain Res. (1997) [Pubmed]
  25. Glycine Binding Sites of Presynaptic NMDA Receptors May Tonically Regulate Glutamate Release in the Rat Visual Cortex. Li, Y.H., Han, T.Z. J. Neurophysiol. (2007) [Pubmed]
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