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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The effect of gastric inhibitory polypeptide on human jejunal water and electrolyte transport.

Using a triple-lumen gut perfusion technique, the net flux of water and electrolytes in the jejunum of 5 healthy volunteers was measured before, during and after an intravenous infusion of gastric inhibitory polypeptide ( GIP). The dose of GIP used (1 mug/min for 30 mins) has previously been shown to raise serum GIP levels to physiological levels achieved in normal subjects after a meal. During GIP infusion, net water Na, K, and HCO3 absorption was significantly reduced and chloride flux was switched from absorption to secretion when compared to pre- and post- GIP control periods (p less than 0.001).[1]

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