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Fu, P.P. et al.

Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice.

Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.[1]

References

Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice. Fu, P.P., Dooley, K.L., Von Tungeln, L.S., Bucci, T., Hart, R.W., Kadlubar, F.F. Carcinogenesis (1994) [Pubmed]

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