Effects of d-amphetamine, methaqualone, and phencyclidine on the reaction time of pigeons.
The effects of acute administrations of d-amphetamine (0.56, 1.0, 1.78, 3.2, and 5.6 mg/kg), methaqualone (5.6, 10, 18, 32, and 56 mg/kg), and phencyclidine (0.3, 0.56, 1.0, and 1.78 mg/kg) on the reaction time of pigeons were examined. In the reaction time assay, birds were trained to depress and hold a foot treadle until a stimulus change occurred. Releases within 2 s of the stimulus change were reinforced with food; premature releases or releases occurring after the 2-s limited hold were not reinforced. At relatively high doses, each of the drugs decreased the percentage of responses that were reinforced. Methaqualone and phencyclidine usually increased median reaction times at these doses, whereas the effects of d-amphetamine on reaction time were less clear.[1]References
- Effects of d-amphetamine, methaqualone, and phencyclidine on the reaction time of pigeons. Kaczor, T., Blakely, E., Poling, A. Pharmacol. Biochem. Behav. (1993) [Pubmed]
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