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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos.

The fibroblast growth factor (FGF)/receptor system is thought to mediate various developmental events in vertebrates. We examined molecular structures and expression of DFR1 and DFR2, two Drosophila genes closely related to vertebrate FGF-receptor genes. DFR1 and DFR2 proteins contain two and five immunoglobulin-like domains, respectively, in the extracellular region, and a split tyrosine kinase domain in the intracellular region. In early embryos, DFR1 RNA expression, requiring both twist and snail proteins, is specific to mesodermal primordium and invaginated mesodermal cells. At later stages, putative muscle precursor cells and cells in the central nervous system (CNS) express DFR1. DFR2 expression occurs in endodermal precursor cells, CNS midline cells and certain ectodermal cells such as those of trachea and salivary duct. FGF-receptor homologues in Drosophila would thus appear essential for generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation.[1]


  1. Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos. Shishido, E., Higashijima, S., Emori, Y., Saigo, K. Development (1993) [Pubmed]
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