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MeSH Review

Salivary Ducts

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Disease relevance of Salivary Ducts

  • These results suggest that inactivation of p16 is important in the development or progression of at least some salivary duct carcinomas, but we found no evidence that its alteration plays a role in the other subtypes examined [1].
  • The relatively poor clinical outcome of the patients in our study mirrored that seen in usual-type salivary duct carcinoma and emphasizes the importance of differentiating mucin-rich salivary duct carcinoma from pure mucinous (colloid) adenocarcinoma, a tumor not fully defined, but possibly with a better prognosis [2].
  • Small quantities of mucin have often been described in salivary duct carcinoma but not large extracellular mucinous lakes, which though prominent in the present series, were not as extensive as in mucinous adenocarcinoma [2].
  • Oral manifestations included hypodontia, microdontia, unerupted mandibular premolars with well formed roots, large dental pulp spaces, enamel hypoplasia, multiple caries, glossy tongue, and congenital absence of lingual frenum and of sublingual caruncles including submandibular and sublingual salivary duct openings [3].
  • Recently, it has been shown that the inducible isoform of the enzyme nitric oxide synthase, iNOS, is expressed in both salivary ducts and pleomorphic adenoma [4].

High impact information on Salivary Ducts


Chemical compound and disease context of Salivary Ducts


Biological context of Salivary Ducts

  • To our knowledge, this is the first molecular genetic analysis of HER-2/neu in salivary duct carcinoma [13].
  • In the present study, double immunohistochemical labeling for Ki 67 and alpha-actin or different cytokeratin subtypes, respectively, made possible an exact localization and quantification of cellular proliferation in the regular salivary duct and in different types of metaplasia [14].
  • PRP may be of biological significance in maintaining homeostasis of the buffering system of saliva, which is mainly composed of bicarbonate, and in preventing the formation of stones consisting of CaCO3 in the salivary ducts [15].
  • Our findings suggest that HGF may play an important role in the development of salivary ducts of normal salivary tissues and differentiation of ductal structures of their neoplasms, while HGF kinetics in saliva and serum would be less likely to reflect the neoplastic character, benign or malignant [16].
  • A review of known functions of prolactin in man and other animals is presented, and it was concluded that normal human minor salivary gland tissue possesses binding sites for prolactin, which suggests that prolactin may play a role in the metabolic functioning of the salivary duct cells [17].

Anatomical context of Salivary Ducts


Associations of Salivary Ducts with chemical compounds

  • In the preceding manuscript (Zhao, H., Xu, X., Diaz, J., and Muallem, S. (1995) J. Biol. Chem. 270, 19599-19605), we described a Kout(+)-dependent H+/HCO3- and Na+ influx pathway in the luminal membrane of salivary duct cells [23].
  • The overall findings support a significant role for the Kout(+)-dependent pathway(s) in Na+ reabsorption and K+ and HCO3- secretion and explain several features of transepithelial electrolyte transport by salivary ducts [23].
  • Finally, we show that changes in redox potential and Zn(2+) are regulating, via SOCC activity, the agonist-induced Ca(2+) response in salivary ducts [24].
  • 1. We have previously reported that the Na+ conductance in mouse intralobular salivary duct cells is controlled by cytosolic anions, being inhibited by high cytosolic concentrations of Cl- and NO3- but not of glutamate [25].
  • Dopamine-induced graded intracellular Ca2+ elevation via the Na+Ca2+ exchanger operating in the Ca2+-entry mode in cockroach salivary ducts [26].

Gene context of Salivary Ducts


Analytical, diagnostic and therapeutic context of Salivary Ducts


  1. Analysis of chromosome 9p21 deletion and p16 gene mutation in salivary gland carcinomas. Cerilli, L.A., Swartzbaugh, J.R., Saadut, R., Marshall, C.E., Rumpel, C.A., Moskaluk, C.A., Frierson, H.F. Hum. Pathol. (1999) [Pubmed]
  2. Mucin-rich variant of salivary duct carcinoma: a clinicopathologic and immunohistochemical study of four cases. Simpson, R.H., Prasad, A.R., Lewis, J.E., Skálová, A., David, L. Am. J. Surg. Pathol. (2003) [Pubmed]
  3. Rapp-Hodgkin syndrome with palmoplantar keratoderma, glossy tongue, congenital absence of lingual frenum and of sublingual caruncles: newly recognized findings. Kantaputra, P.N., Pruksachatkunakorn, C., Vanittanakom, P. Am. J. Med. Genet. (1998) [Pubmed]
  4. Are myoepithelial cells responsible for the widespread expression of inducible nitric oxide synthase in pleomorphic adenoma? An immunohistochemical study. Brennan, P.A., Umar, T., Zaki, G.A., Langdon, J.D., Spedding, A., Buckley, J., Downie, I.P. J. Oral Pathol. Med. (2000) [Pubmed]
  5. Inhibition by alcohols of the localization of radioactive nitrosonornicotine in sites of tumor formation. Waddell, W.J., Marlowe, C. Science (1983) [Pubmed]
  6. Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+. Dinudom, A., Harvey, K.F., Komwatana, P., Young, J.A., Kumar, S., Cook, D.I. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. Regulation of bHLH-PAS protein subcellular localization during Drosophila embryogenesis. Ward, M.P., Mosher, J.T., Crews, S.T. Development (1998) [Pubmed]
  8. The Drosophila Pax gene eye gone is required for embryonic salivary duct development. Jones, N.A., Kuo, Y.M., Sun, Y.H., Beckendorf, S.K. Development (1998) [Pubmed]
  9. Salivary duct determination in Drosophila: roles of the EGF receptor signalling pathway and the transcription factors fork head and trachealess. Kuo, Y.M., Jones, N., Zhou, B., Panzer, S., Larson, V., Beckendorf, S.K. Development (1996) [Pubmed]
  10. Thyroid hormones and renin secretion. Ganong, W.F. Life Sci. (1982) [Pubmed]
  11. Sialolith crystals localized intraglandularly and in the Wharton's duct of the human submandibular gland: an X-ray diffraction analysis. Teymoortash, A., Buck, P., Jepsen, H., Werner, J.A. Arch. Oral Biol. (2003) [Pubmed]
  12. Incidence of Wharton's duct stenosis in floor of the mouth cancers excised with scalpel or cautery vs CO2 laser. Mihail, R., Zajtchuk, J.T., Davis, R.K. Head & neck surgery. (1987) [Pubmed]
  13. Expression of HER-2/neu gene and protein in salivary duct carcinomas of parotid gland as revealed by fluorescence in-situ hybridization and immunohistochemistry. Skálová, A., Stárek, I., Vanecek, T., Kucerová, V., Plank, L., Szépe, P., Di Palma, S., Leivo, I. Histopathology (2003) [Pubmed]
  14. A morphogenetic concept of salivary duct regeneration and metaplasia. Ihrler, S., Zietz, C., Sendelhofert, A., Lang, S., Blasenbreu-Vogt, S., Löhrs, U. Virchows Arch. (2002) [Pubmed]
  15. Inhibition of calcium-carbonate precipitation by human salivary proline-rich phosphoproteins. Saitoh, E., Isemura, S., Sanada, K. Arch. Oral Biol. (1985) [Pubmed]
  16. Association of hepatocyte growth factor expression with salivary gland tumor differentiation. Tsukinoki, K., Yasuda, M., Asano, S., Karakida, K., Ota, Y., Osamura, R.Y., Watanabe, Y. Pathol. Int. (2003) [Pubmed]
  17. Prolactin binding in normal human minor salivary gland tissue: an immunohistochemical study. Abbey, L.M., Witorsch, R.J. Oral Surg. Oral Med. Oral Pathol. (1984) [Pubmed]
  18. Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos. Shishido, E., Higashijima, S., Emori, Y., Saigo, K. Development (1993) [Pubmed]
  19. Immunologic characterization of the mononuclear cell infiltrates in rheumatoid synovia, in rheumatoid nodules, and in lip biopsies from patients with Sjögren's syndrome. Tannenbaum, H., Pinkus, G.S., Anderson, L.G., Schur, P.H. Arthritis Rheum. (1975) [Pubmed]
  20. Specification of cell fates within the salivary gland primordium. Haberman, A.S., Isaac, D.D., Andrew, D.J. Dev. Biol. (2003) [Pubmed]
  21. Expression of epidermal growth factor and its mRNA in pig kidney, pancreas and other tissues. Vaughan, T.J., Pascall, J.C., James, P.S., Brown, K.D. Biochem. J. (1991) [Pubmed]
  22. Homologous carcinomas of the breasts, skin, and salivary glands. A histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma. Wick, M.R., Ockner, D.M., Mills, S.E., Ritter, J.H., Swanson, P.E. Am. J. Clin. Pathol. (1998) [Pubmed]
  23. Regulation of [Na+]i in resting and stimulated submandibular salivary ducts. Xu, X., Zhao, H., Diaz, J., Muallem, S. J. Biol. Chem. (1995) [Pubmed]
  24. Inhibitory mechanism of store-operated Ca2+ channels by zinc. Gore, A., Moran, A., Hershfinkel, M., Sekler, I. J. Biol. Chem. (2004) [Pubmed]
  25. Control of the amiloride-sensitive Na+ current in mouse salivary ducts by intracellular anions is mediated by a G protein. Dinudom, A., Komwatana, P., Young, J.A., Cook, D.I. J. Physiol. (Lond.) (1995) [Pubmed]
  26. Dopamine-induced graded intracellular Ca2+ elevation via the Na+Ca2+ exchanger operating in the Ca2+-entry mode in cockroach salivary ducts. Hille, C., Walz, B. Cell Calcium (2006) [Pubmed]
  27. Expression of androgen receptor, gross cystic disease fluid protein, and CD44 in salivary duct carcinoma. Kapadia, S.B., Barnes, L. Mod. Pathol. (1998) [Pubmed]
  28. Expression of androgen receptor, epidermal growth factor receptor, and transforming growth factor alpha in salivary duct carcinoma. Fan, C.Y., Melhem, M.F., Hosal, A.S., Grandis, J.R., Barnes, E.L. Arch. Otolaryngol. Head Neck Surg. (2001) [Pubmed]
  29. Increase in the ratio of matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 in saliva from patients with primary Sjögren's syndrome. Asatsuma, M., Ito, S., Watanabe, M., Takeishi, H., Nomura, S., Wada, Y., Nakano, M., Gejyo, F., Igarashi, A. Clin. Chim. Acta (2004) [Pubmed]
  30. Dopamine and serotonin receptors mediating contractions of the snail, Helix pomatia, salivary duct. Kiss, T., Hiripi, L., Papp, N., Elekes, K. Neuroscience (2003) [Pubmed]
  31. Secretion of glandular kallikrein and renin from the basolateral pole of mouse submandibular duct cells: an immunocytochemical study. Penschow, J.D., Coghlan, J.P. J. Histochem. Cytochem. (1993) [Pubmed]
  32. Fluid secretion by isolated tick salivary glands dependent on an intact cytoskeleton. Lamoreaux, W.J., Needham, G.R., Coons, L.B. Int. J. Parasitol. (1994) [Pubmed]
  33. Autoantibodies to keratin in Sjögren's syndrome. Saku, T., Shibata, Y., Cheng, J., Okabe, H., Ikari, N., Yagi, Y. J. Oral Pathol. Med. (1990) [Pubmed]
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