The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Tyrosine phosphorylation of P160 BCR by P210 BCR- ABL.

It is well established that the chimeric BCR- ABL gene formed by joining parts of the BCR and ABL genes plays a key role in the pathogenesis of Philadelphia (Ph) chromosome-positive leukemias. We report that simultaneous expression of P210 BCR- ABL and P160 BCR in simian COS-1 cells yielded stable complexes of these two proteins, and induced phosphorylation of P160 BCR on tyrosine residues in vivo. Tyrosine phosphorylation of a deletion mutant encoding 553 amino acids of BCR N-terminal sequences was also detected when it was coexpressed with P210 BCR- ABL. We propose that tyrosine phosphorylation of P160 BCR by P210 BCR- ABL and their stable physical interaction may perturb normal BCR functions and that these alterations are directly involved in the pathologic processes found in Ph chromosome-associated leukemias.[1]


  1. Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL. Lu, D., Liu, J., Campbell, M., Guo, J.Q., Heisterkamp, N., Groffen, J., Canaani, E., Arlinghaus, R. Blood (1993) [Pubmed]
WikiGenes - Universities