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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

ADP-ribosylation of nucleolar proteins in HeLa tumor cells.

ADP-ribosylation reactions in nucleoli of exponentially growing HeLa cells were studied. Isolated nuclei or nucleoli were labeled with 32P-NAD; then the nucleolar proteins were analyzed by 1-dimensional and 2-dimensional polyacrylamide gel electrophoresis (PAGE) and modified proteins were detected by autoradiography. The labeled nucleolar proteins were also chromatographically fractionated on DEAE-cellulose. Electrophoretic analysis of total nucleolar and chromatographically purified proteins revealed that besides nuclear ADP-ribosyltransferase and histones two characteristic nucleolar phosphoproteins numatrin/B23 and nucleolin/C23 were modified by ADP-ribosylation.[1]


  1. ADP-ribosylation of nucleolar proteins in HeLa tumor cells. Leitinger, N., Wesierska-Gadek, J. J. Cell. Biochem. (1993) [Pubmed]
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