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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of interleukin-6 on cell proliferation of FRTL-5 cells.

We studied the effects of interleukin-6(IL-6) on DNA synthesis and cyclic AMP production in rat thyroid FRTL-5 cells. When cells were incubated with IL-6 in the presence or absence of IGF-I, cell proliferation was not observed. By contrast, IL-6 stimulated DNA synthesis in a dose dependent manner when TSH was added concomitantly. On the other hand, IL-6 did not modulate the cAMP accumulation in the presence or absence of TSH. These data demonstrate that, like IGF-I, IL-6 may be able to act as a growth factor through activation of a mitogenic signal transduction pathway different from A-kinase in FRTL-5 cells.[1]

References

  1. Effect of interleukin-6 on cell proliferation of FRTL-5 cells. Nishiyama, S., Takada, K., Tada, H., Takano, T., Amino, N. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
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